Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques

Hong, Myeng Chan; Kim, Yun Kyung; Choi, Jae Yong; Yang, Si Qiang; Rhee, Hakjune; Ryu, Young Hoon; Choi, Tae Hyun; Cheon, Gi Jeong; An, Gwang Il; Kim, Hye Yun; Kim, Youngsoo; Kim, Dong Jin; Lee, Jung Hoon; Chang, Young‐Tae; Lee, Kyo Chul

doi:10.1016/j.bmc.2010.06.044

Cited by 38 publications

(12 citation statements)

References 17 publications

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“…In human trials of the radiotracer initially conducted, 11 C-SB-13 demonstrated significant levels of localization in known regions of A β accumulation as a part of AD pathogenesis [ 115 ]. This was possible due to efficient transport of the radiotracer across the blood brain barrier [ 116 ]. Rather, studies have indicated that the relative cortical uptake of 11 C-SB-13 is greater than that of 11 C-PIB [ 117 ].…”

Section: Radiotracers For Amyloid Imagingmentioning

confidence: 99%

Insight into the Molecular Imaging of Alzheimer’s Disease

Arora

Bhagat

2016

International Journal of Biomedical Imaging

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Alzheimer's disease is a complex neurodegenerative disease affecting millions of individuals worldwide. Earlier it was diagnosed only via clinical assessments and confirmed by postmortem brain histopathology. The development of validated biomarkers for Alzheimer's disease has given impetus to improve diagnostics and accelerate the development of new therapies. Functional imaging like positron emission tomography (PET), single photon emission computed tomography (SPECT), functional magnetic resonance imaging (fMRI), and proton magnetic resonance spectroscopy provides a means of detecting and characterising the regional changes in brain blood flow, metabolism, and receptor binding sites that are associated with Alzheimer's disease. Multimodal neuroimaging techniques have indicated changes in brain structure and metabolic activity, and an array of neurochemical variations that are associated with neurodegenerative diseases. Radiotracer-based PET and SPECT potentially provide sensitive, accurate methods for the early detection of disease. This paper presents a review of neuroimaging modalities like PET, SPECT, and selected imaging biomarkers/tracers used for the early diagnosis of AD. Neuroimaging with such biomarkers and tracers could achieve a much higher diagnostic accuracy for AD and related disorders in the future.

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Section: Radiotracers For Amyloid Imagingmentioning

confidence: 99%

Insight into the Molecular Imaging of Alzheimer’s Disease

Arora

Bhagat

2016

International Journal of Biomedical Imaging

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“…The harsh reaction conditions, expensive synthetic steps, or small differences in the E:Z ratio reported in the literature inspired us to devise a different route with milder and more economical synthetic steps. Dibromo‐substituted ( E )‐stilbene 3 and 4 were synthesized via Horner‐Wadsworth‐Emmons (HWE) reaction starting from phosphonates 1 and 2 , respectively. This route could be easily scaled up.…”

Section: Resultsmentioning

confidence: 99%

“…, entries[25][26][27][28][29][30][31][32]. It was noted that in the presence of 1-naphtaldehyde, good to excellent enantioselectivities were observed under the catalysis of all four ligands in toluene(Table 1,entries 34, 36, 38, and 40).…”

mentioning

confidence: 99%

EnantioselectiveEthylation of Various Aldehydes Catalyzed by Readily Accessible Chiral Diols

et al. 2016

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Four chiral C2 -symmetric diols were synthesized in a straightforward three-step reaction and demonstrated excellent enantioselectivities and good overall yields. Their catalytic activities were examined via the addition of diethylzinc to various aldehydes. The enantioselective addition of diethylzinc to 2-methoxybenzaldehyde gave the corresponding chiral secondary alcohol with high yields (up to 95%) and moderate to good enantiomeric excess (up to 88%). All synthesized ligands were evaluated in the addition of diethylzinc to various aldehydes in the presence of an additional metal such as Ti(IV) complexes. Chirality 28:593-598, 2016. © 2016 Wiley Periodicals, Inc.

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“…synthesized 34 stilbene anlogues with various electron withdrawing and donating groups, and found four compounds exhibited more than a 6-fold fluorescence intensity increase. Remarkably, compound 2 displayed high fluorescence responsiveness (>25-fold increase) and strong binding affinity, and clearly labeled the peripheral region of Aβ plaques in brain slices [64]. …”

Section: Amyloid-βmentioning

confidence: 99%

Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins

Zhang¹,

Ran²

2013

COC

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Misfolding of a protein is a destructive process for variety of diseases that include neurodegenerative diseases such as Alzheimer’s disease, Parkinson disease, Huntington disease, mad cow disease, amyotrophic lateral sclerosis (ALS), and frontal temporal dementia (FTD), and other non-CNS diseases such as diabetes, cystic fibrosis, and lysosomal storage diseases. Formation of various misfunctional large assembles of the misfolded protein is the primary consequence. To detect the formation of the aggregated species is very important for not only basic mechanism research but also very crucial for diagnosis of the diseases. In this review, we updated references related to the new development of the dual functional fluorescent small molecule probes for detecting the aggregated proteins in vitro and in vivo.

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Synthesis and evaluation of stilbene derivatives as a potential imaging agent of amyloid plaques

Cited by 38 publications

References 17 publications

Insight into the Molecular Imaging of Alzheimer’s Disease

Insight into the Molecular Imaging of Alzheimer’s Disease

EnantioselectiveEthylation of Various Aldehydes Catalyzed by Readily Accessible Chiral Diols

Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins

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