Synthesis and Evaluation of the Anti-corrosion Activity of Thiosemicarbazide and Thiosemicarbazone 4-<i>N</i>-(<i>p</i>-methoxyphenyl) Substituted

Sousa-Pereira, Danilo; Goulart, Carla Marins; Reis, Cristiane Marques dos; Echevarrı́a, Aurea

doi:10.5935/1984-6835.20130055

Cited by 4 publications

(5 citation statements)

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“…Finally, the peaks at 1352 and 1230 cm -1 correspond to the C-C and C-OH stretching vibration of carboxylic groups. 27 Relating to Vulcan-CBZ spectrum ( Figure S1b) the presence of characteristic stretches of thiosemicarbazide functional groups can be clearly observed ( Figure S1c): 22,28,29 u(C=S) 840-730 cm -1 , u(N-N) 1037-840 cm -1 and u(N-H) 3368-3175 cm -1 . It is also noted that the peak assigned to N-H centered at 3363 cm -1 underwent a slight change.…”

Section: Characterization Of Materialsmentioning

confidence: 99%

“…Indeed, thiosemicarbazones are able to form stable complexes with some metallic cations, such as zinc, copper and iron. 21,22 The analytical curves obtained (Figure 1b) showed a good linear range for all electrodes. However, special sensitivity was reached while using CPE/Vulcan-CBZ (0.18 µA nmol -1 L) in comparison to CPE/Vulcan (0.04 µA nmol -1 L) and unmodified CPE (0.03 µA nmol -1 L).…”

Section: Characterization Of Materialsmentioning

confidence: 99%

“…19,20 This material has oxygenated surface groups that may be useful for the generation of thiosemicarbazones, which present important properties to form stable complexes with some metal cations. [21][22][23][24][25] This work describes the synthesis and application of the Vulcan-cabarzone composite (Vulcan-CBZ) for the determination of copper ions (Cu 2+ ) in complex samples, such as biodiesel, aiming to the development of a stable, sensitive and selective voltammetric sensor. Additionally, to the best of our knowledge, there is no report available that addresses the modification of Vulcan with tiosemicarbazide and its applications.…”

Section: Introductionmentioning

confidence: 99%

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Development of a Novel and Simple Electroanalytical Procedure for the Determination of Copper in Biofuel Employing a Sensor Based on Vulcan Functionalized with Carbazone

Freitas¹,

Lima²,

Marques³

et al. 2018

J. Braz. Chem. Soc.

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A novel and simple electroanalytical method for the determination of Cu 2+ in biodiesel samples by stripping voltammetric analysis was developed. The method employs a carbon paste electrode (CPE) modified with Vulcan carbon, previouly functionalized with carbazone (CBZ). The CPE/Vulcan-CBZ sensor promoted a significant increase in the analytical signal obtained from copper as compared to unmodified CPE, and the CPE modified with Vulcan carbon (CPE/ Vulcan). Vulcan-CBZ, Vulcan and CBZ materials were characterized by Fourier transform infrared spectroscopy (FTIR) technique. The electrochemical behavior of the sensor was evaluated using cyclic voltammetry (CV) and square-wave anodic stripping voltammetric (SWASV) techniques. The CPE/Vulcan-CBZ modified electrode showed excellent response and was able to detect Cu 2+ at nanomolar levels. The electrochemical method is based on preconcentration of Cu 2+ ions on the CPE/Vulcan-CBZ at 0.35 V vs. Ag/AgCl(sat) in 0.2 mol L -1 ammonium sulfate solution ((NH 4 ) 2 SO 4 ), pH 3.5, during 120 s, followed by subsequent chemical stripping. The analytical signal showed a linear response for Cu 2+ concentrations in the range from 6 to 190 nmol L -1 (r = 0.998), with a detection limit of 1.2 nmol L -1 . The sensor was successfully applied for the determination of Cu 2+ in biodiesel and the average recovery varied between 97.0 and 102.8% for the soybean biodiesel samples and between 109.6 and 111.0% for the babassu biodiesel samples showing a good accuracy for the proposed method.Keywords: biofuel, copper, voltammetric sensor, Vulcan carbon, carbazone IntroductionThe pursuit of alternative fuels has been acquiring prominence in the last decades. The replacement of fossil fuels has been motivated by environmental, economical and social factors, since society itself depends on its use. In this context, one alternative that has stood out is the use of biofuels, such as charcoal, alcohol, biogas and biodiesel. 1,2 Biodiesel is a renewable fuel produced either from vegetable sources (soybean, castor oil, palm oil, sunflower, among others) or from ethanol (from sugarcane) or methanol (which can be obtained from wood biomass). 3 It is, therefore, a biodegradable, sustainable and environmentally friendly fuel. However, some metals, such as Cu, Fe, and Ni, can be inserted in the production process with the catalysts, during transportation and storage. Furthermore, the presence of these metals, even at trace levels, can promote the formation of gums and sediments that damage vehicle engines and promote the oxidation of biodiesel. 4,5 Copper, iron and the effect of nickel on biodiesel's stability has been widely evaluated. Among these metals, copper is the most powerful catalyst in biodiesel's oxidation process. 5 Therefore, the monitoring of the amount of copper is extremely important in this fuel for preventing undesirable variations in its physical state and properties, during its use or storage. 5 In this context, it is opportune and necessary to develop novel sensitive and selective anal...

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Section: Characterization Of Materialsmentioning

confidence: 99%

Section: Characterization Of Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of a Novel and Simple Electroanalytical Procedure for the Determination of Copper in Biofuel Employing a Sensor Based on Vulcan Functionalized with Carbazone

Freitas¹,

Lima²,

Marques³

et al. 2018

J. Braz. Chem. Soc.

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“…Different TSC derivatives have been synthesized and evaluated against several pathogens [10,11]. The TSC's biological effects have been described as antifungal, antibacterial, antioxidant, and antitumor [12][13][14]. As antifungal drug, TSC was positively evaluated Deize Evangelista Araújo and Amanda Alves de Oliveira contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Investigation of thiosemicarbazide free or within chitosan nanoparticles in a murine model of vulvovaginal candidiasis

et al. 2020

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Vulvovaginal candidiasis is a serious health problem affecting numerous women around the world. Its treatment is based on antifungals which may not provide an effective cure because of the resistance presented by its etiological pathogens Candida spp. Candida albicans is the most prevalent species related to vulvovaginal candidiasis. Here, we evaluated the in vivo antifungal potential of thiosemicarbazide and thiosemicarbazide encapsulated within chitosan nanoparticles in a murine model of vulvovaginal candidiasis. The results demonstrated the antifungal capacity of free or nanoencapsulated thiosemicarbazide within chitosan to reduce the fungal load in the vaginal tissue of infected mice. In addition, histological analyses indicated the absence or a mild to moderate infection in thiosemicarbazide-treated groups. Statistical tests confirmed the existence of significant differences between the treated and the control groups. Therefore, our results suggest a potential application of thiosemicarbazide and encapsulated thiosemicarbazide as an alternative vulvovaginal candidiasis therapy.

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“…Thiosemicarbazides (TSCs) are important molecules in organic synthesis, as they are easily modifiable and can undergo structural modifications to produce different compounds for many applications. TSCs are obtained by the reaction of isothiocyanates and hydrazines [ 17 ]; many TSC derivatives have shown biological effects, such as anticonvulsant [ 18 ], antimicrobial [ 19 ], antitumor [ 20 ], antituberculosis [ 21 ], antiparasitic [ 22 ], and antioxidant [ 23 ] activities. Monoterpenoids are also very biologically significant molecules, obtained from essentials oils of plants, which possess a wide range of bioactive properties.…”

Section: Introductionmentioning

confidence: 99%

Chemoproteomic identification of molecular targets of antifungal prototypes, thiosemicarbazide and a camphene derivative of thiosemicarbazide, in Paracoccidioides brasiliensis

et al. 2018

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Paracoccidioidomycosis (PCM) is a neglected human systemic disease caused by species of the genus Paracoccidioides. The disease attacks the host’s lungs and may disseminate to many other organs. Treatment involves amphotericin B, sulfadiazine, trimethoprim-sulfamethoxazole, itraconazole, ketoconazole, or fluconazole. The treatment duration is usually long, from 6 months to 2 years, and many adverse effects may occur in relation to the treatment; co-morbidities and poor treatment adherence have been noted. Therefore, the discovery of more effective and less toxic drugs is needed. Thiosemicarbazide (TSC) and a camphene derivative of thiosemicarbazide (TSC-C) were able to inhibit P. brasiliensis growth at a low dosage and were not toxic to fibroblast cells. In order to investigate the mode of action of those compounds, we used a chemoproteomic approach to determine which fungal proteins were bound to each of these compounds. The compounds were able to inhibit the activities of the enzyme formamidase and interfered in P. brasiliensis dimorphism. In comparison with the transcriptomic and proteomic data previously obtained by our group, we determined that TSC and TSC-C were multitarget compounds that exerted effects on the electron-transport chain and cell cycle regulation, increased ROS formation, inhibited proteasomes and peptidases, modulated glycolysis, lipid, protein and carbohydrate metabolisms, and caused suppressed the mycelium to yeast transition.

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Synthesis and Evaluation of the Anti-corrosion Activity of Thiosemicarbazide and Thiosemicarbazone 4-N-(p-methoxyphenyl) Substituted

Cited by 4 publications

References 0 publications

Development of a Novel and Simple Electroanalytical Procedure for the Determination of Copper in Biofuel Employing a Sensor Based on Vulcan Functionalized with Carbazone

Development of a Novel and Simple Electroanalytical Procedure for the Determination of Copper in Biofuel Employing a Sensor Based on Vulcan Functionalized with Carbazone

Investigation of thiosemicarbazide free or within chitosan nanoparticles in a murine model of vulvovaginal candidiasis

Chemoproteomic identification of molecular targets of antifungal prototypes, thiosemicarbazide and a camphene derivative of thiosemicarbazide, in Paracoccidioides brasiliensis

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