Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives

Abstract

A series of new pyrazolo[3,4-d]pyrimidine compounds were synthesized in excellent yields via sulfuration and 1,3-dipolar cycloaddition and confirmed by MS, FT-IR and NMR techniques. All the prepared compounds were screened in vitro for their α-amylase and αglucosidase inhibitory activities. Preliminary results indicated that some target compounds exhibited promising α-amylase and α-glucosidase inhibitory activity potency. Among the tested products, the cycloadduct f was found most active inhibitor (IC50 = 134.30 μM) for αamylase, and the sulphur product b is the most active inhibitor (IC50 = 16.37 μM) for αglucosidase.

Synthesis, structural characterisation and theoretical studies of a novel pyridazine derivative: Investigations of anti-inflammatory activity and inhibition of α-glucosidase

“…2, in order to ascertain the influence of the methyl group in 1 upon the molecular packing. Further, based on the wide biological interest of pyridazine derivatives, alluded to above, and due to our continuing interests on the synthesis of heterocyclic systems with remarkable anti-inflammatory and anti-diabetic activities [23][24][25], 1 was also evaluated for anti-inflammatory and enzyme inhibitory activities using an α-Glucosidase inhibition assay.…”