Synthesis and Fabrication of Nanocomposite Fibers of Collagen-Cellulose Nanocrystals by Coelectrocompaction

Cudjoe, Elvis; Younesi, Mousa; Cudjoe, Edward; Akkuş, Ozan; Rowan, Stuart J.

doi:10.1021/acs.biomac.7b00005

Cited by 21 publications

(17 citation statements)

References 48 publications

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“…Collagen is an example of a mechanically functional protein that has been combined with charged CNC. By an isoelectric focusing technique, aligned fibers were formed that were stiffened by 5% CNC and showed enhancement in wet mechanical properties . Other proteins that are typically not associated with mechanical properties, such as plant storage proteins (prolamins), have been explored for mechanical functions through processing by electrospinning .…”

Section: Nanocelluloses As Colloidal‐level Structural Unitsmentioning

confidence: 99%

Advanced Materials through Assembly of Nanocelluloses

et al. 2018

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There is an emerging quest for lightweight materials with excellent mechanical properties and economic production, while still being sustainable and functionalizable. They could form the basis of the future bioeconomy for energy and material efficiency. Cellulose has long been recognized as an abundant polymer. Modified celluloses were, in fact, among the first polymers used in technical applications; however, they were later replaced by petroleum-based synthetic polymers. Currently, there is a resurgence of interest to utilize renewable resources, where cellulose is foreseen to make again a major impact, this time in the development of advanced materials. This is because of its availability and properties, as well as economic and sustainable production. Among cellulose-based structures, cellulose nanofibrils and nanocrystals display nanoscale lateral dimensions and lengths ranging from nanometers to micrometers. Their excellent mechanical properties are, in part, due to their crystalline assembly via hydrogen bonds. Owing to their abundant surface hydroxyl groups, they can be easily modified with nanoparticles, (bio)polymers, inorganics, or nanocarbons to form functional fibers, films, bulk matter, and porous aerogels and foams. Here, some of the recent progress in the development of advanced materials within this rapidly growing field is reviewed.

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Section: Nanocelluloses As Colloidal‐level Structural Unitsmentioning

confidence: 99%

Advanced Materials through Assembly of Nanocelluloses

et al. 2018

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“…However, with the current EDC/NHS crosslinking method, the amount of SXRGlu that can be introduced into the ECLC matrices is limited, well below the composition of polysaccharides in native skin, among which collagen and polysaccharides account for 75% and 20% dry weight respectively. An alternative approach to improve SXRGlu loading is to develop SXRGlu derivatives that can carry both positive charge and negative charge, sharing the same isoelectric point with collagen [19]. In this way, SXRGlu and collagen can be co-electrocompacted at any ratio.…”

Section: Resultsmentioning

confidence: 99%

Fabrication and In Vitro Characterization of Electrochemically Compacted Collagen/Sulfated Xylorhamnoglycuronan Matrix for Wound Healing Applications

Liu

Yue

et al. 2018

Polymers

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Skin autografts are in great demand due to injuries and disease, but there are challenges using live tissue sources, and synthetic tissue is still in its infancy. In this study, an electrocompaction method was applied to fabricate the densely packed and highly ordered collagen/sulfated xylorhamnoglycuronan (SXRGlu) scaffold which closely mimicked the major structure and components in natural skin tissue. The fabricated electrocompacted collagen/SXRGlu matrices (ECLCU) were characterized in terms of micromorphology, mechanical property, water uptake ability and degradability. The viability, proliferation and morphology of human dermal fibroblasts (HDFs) cells on the fabricated matrices were also evaluated. The results indicated that the electrocompaction process could promote HDFs proliferation and SXRGlu could improve the water uptake ability and matrices' stability against collagenase degradation, and support fibroblast spreading on the ECLCU matrices. Therefore, all these results suggest that the electrocompacted collagen/SXRGlu scaffold is a potential candidate as a dermal substitute with enhanced biostability and biocompatibility.

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“…The advantages and disadvantages of nanocellulose and collagen can effectively complement each other to form a more potential nanocomposite material (Cudjoe et al 2017), which makes their composites have a broader application prospect. However, the interactions between nanocellulose and collagen, which are significantly related to the strength of composites, are still obscure.…”

Section: Introductionmentioning

confidence: 99%

Effects of Nanocellulose on the Structure of Collagen: Insights from Molecular Dynamics Simulation and Umbrella Sampling

Ning

Shi

et al. 2022

Preprint

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Collagen-nanocellulose composites have been widely used in biomedicine and tissue engineering. However, the detailed mechanism underlying the effects of nanocellulose on the structure of collagen hasn’t been elucidated. As the main component of skin tissue, the conformational disturbance of collagen triggered by nanocellulose may shed light on the biocompatibility of nanocellulose. Therefore, molecular dynamics simulations were carried out to gain insights into the interactions between nanocellulose and collagen. Four different crystal planes of cellulose ((110), (100), (1-10), (010)) have been constructed and the adsorption of collagen onto the four faces has been investigated respectively. It has been found that the structure of collagen remained intact during the binding without chain separation. The intactness of collagen supported the point that the nanocellulose has good biocompatibility. The results derived from umbrella sampling showed that (110) and (1-10) faces exhibit the strongest affinity with collagen, which may be attributed to its hydrophilicity and rather flat surfaces. The hydrophobicity of (100) face and roughness of (010) face diminished the affinity with collagen. The occupancy of hydrogen bonds was low and hydrogen bonding interactions fail to make significant contributions to the binding of nanocellulose and collagen. These findings provided insights into the interactions between cellulose and collagen at an atomic level, which may guide the design and fabrication of collagennanocellulose composites. Furthermore, the biocompatibility of nanocellulose validated in the study may help promote the biological application of nanocellulose involved composites.

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Synthesis and Fabrication of Nanocomposite Fibers of Collagen-Cellulose Nanocrystals by Coelectrocompaction

Cited by 21 publications

References 48 publications

Advanced Materials through Assembly of Nanocelluloses

Advanced Materials through Assembly of Nanocelluloses

Fabrication and In Vitro Characterization of Electrochemically Compacted Collagen/Sulfated Xylorhamnoglycuronan Matrix for Wound Healing Applications

Effects of Nanocellulose on the Structure of Collagen: Insights from Molecular Dynamics Simulation and Umbrella Sampling

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