Synthesis and Fluorescence Properties of new Monastrol Analogs Conjugated Fluorescent Coumarin Scaffolds

Al‐Masoudi, Najim A.; Al-Salihi, Niran J.; Marich, Yossra A.; Markus, Timo

doi:10.1007/s10895-015-1695-x

Cited by 9 publications

(1 citation statement)

References 20 publications

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“…Estes derivados formam DHPMs que possuem propriedades fluorescentes, sendo que alguns podem ser utilizados como sondas de pH. 16,37,38 18,35 Esse comportamento é observado pelo fato de os solventes polares possuírem maior capacidade de solvatação e constantes dielétricas elevadas. Estas condições auxiliam a formação e estabilização de intermediários iônicos, sendo esta estabilização a responsável pelo aumento na reatividade das moléculas envolvidas trazendo uma elevação no rendimento final.…”

Section: Variabilidade Dos Reagentes Utilizadosunclassified

Theory Behind Biginelli Reaction Revisited

Tejero

Kümmerle²,

Bauerfeldt³

2019

Rev. Virtual Quim.

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Multicomponent reactions (MCRs) have received great attention in organic and chemical synthesis, since they allow planning of new molecules and pharmaceuticals, in particular, with great structural complexity and in excellent yields. One of the most remarkable MCRs is the Biginelli reaction, which forms the dihydropyrimidinones / thiones product through the reaction of aldehyde, β-ketoester and urea or thiourea. In the mechanism of this reaction three pathways can be expected: the Knoevenagel pathway, the iminium ion pathway and the enamine pathway, as this reaction occurs through bimolecular combinations of the reactants. After several experimental and theoretical studies, it was possible to observe that the mechanism of this reaction occurs preferentially through the formation of iminium ion, but may lead to other initiation pathways, depending on the experimental conditions. The goal of this work is to present the changes in the initiation of the reaction mechanism, in view of the different experimental arrangements, observed through studies conducted for this type of reaction over the years, as well as to discuss the results of theoretical studies that support these experimental observations.

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Section: Variabilidade Dos Reagentes Utilizadosunclassified

Theory Behind Biginelli Reaction Revisited

Tejero

Kümmerle²,

Bauerfeldt³

2019

Rev. Virtual Quim.

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Green Nanospheres Natural Camphor Coated Ferrite as a Highly Efficient Nanocatalyst for the Synthesis of Dihydropyrimidine Derivatives

2017

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Dihydropyrimidines are synthesized by a one-pot condensation of an aldehyde, b-ketoester and urea or thiourea in the presence of Fe 3 O 4 @camphor as a new heterogeneous magnetic nanocatalyst. The nanospheres morphology of the green natural camphor/ferrite was characterized by Fourier transform infrared (FT-IR) spectroscopy, field-emission scanning electron microscopy (FE-SEM) images, X-ray diffraction (XRD) pattern, energy-dispersive X-ray (EDX), vibrating sample magnetometer (VSM), N 2 adsorption-desorption by Brunauer-Emmett-Teller (BET) and inductively coupled plasma (ICP) analyses. The advantages of this new report are short reaction times, high yields, easy workup, low cost and eco-friendly protocol. The recoverable nanocatalyst was simply prepared and effectively employed for the one-pot multicomponent synthesis of dihydropyrimidine derivatives, for the first time, at room temperature.

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