Synthesis and free radical scavenging activity of 4-(2H-1,2,4-benzothiadiazine-1,1-dioxide-3-yl)-2,6-bis(1,1-dimethylethyl)phenols

Tait, Annalisa; Ganzerli, Stefano; Bella, M. Di

doi:10.1016/0040-4020(96)00747-8

Cited by 13 publications

(15 citation statements)

References 16 publications

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“…DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) radical scavenging activity was determined ( n = 3 per treatment) according to Tait et al (). For quantitative evaluation, 100 μL of each extract (0.1 mg mL −1 ) were mixed with 2.9 mL of DPPH solution (200 μ g mL −1 ) (Sigma‐Aldrich, U.S.A.), which was prepared daily.…”

Section: Methodsmentioning

confidence: 99%

Interactive effects of marine heatwaves and eutrophication on the ecophysiology of a widespread and ecologically important macroalga

Gouvêa

Schubert

Martins

et al. 2017

Limnology & Oceanography

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Extreme temperature events are becoming more recurrent and are more frequent with major impacts on coastal ecosystems, which are additionally impacted by increasing urbanization, resulting in high nutrient load. So far little is known about cumulative and/or interactive effects of global and local stressors on species' performance. Here, we evaluated the single and combined effects of simulated heatwaves and eutrophication on the ecophysiology of Laurencia catarinensis in a bi-factorial mesocosm experiment. The algae were exposed for 30 d to three different temperatures (208C, 248C, 288C) and nutrient concentrations (low, intermediate, high) and their nutrient uptake rates, photosynthetic performance, growth rates, pigment and phenolic compound concentrations, as well as antioxidant capacity was determined and compared between treatments. Under low nutrient concentration, physiological performance and growth decreased with increasing temperatures. In contrast, they increased with higher nutrient availability and moderate temperature increase close to the summer average temperature, but largely declined upon exposure to higher temperature (288C). This decline seemed to be related to oxidative stress, as indicated by an increase of compounds with antioxidant properties (lutein, zeaxanthin, phenols). Our data show that all measured parameters were affected by temperature and nutrient availability, with an interactive effect between these two factors, indicating that increasing temperature will influence macroalgal performance, and even more dramatically in coastal systems that are highly impacted by urbanization. However, the direction of the response will be determined by nutrient availability and will also depend on the magnitude of the temperature increase, that is, whether it surpasses the thermal threshold of the species.Marine macroalgae are dominant and essential components of coastal ecosystems around the world (Gattuso et al. 1998;Harley et al. 2012) and are currently threatened by a multitude of stressors, such as those related to global climate change (Harley et al. 2006(Harley et al. , 2012, but also locally by increasing nutrient and sediment loading, the overfishing and spread of invasive species (Worm and Lotze 2006;Schmidt and Scheibling 2007). Current changes in seawater temperature, due to climatic change, predict for the end of this century a continuous warming of near-surface air temperature, on the order of 2-78C with regional, seasonal and diurnal

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Section: Methodsmentioning

confidence: 99%

Interactive effects of marine heatwaves and eutrophication on the ecophysiology of a widespread and ecologically important macroalga

Gouvêa

Schubert

Martins

et al. 2017

Limnology & Oceanography

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“…no. Retention time (min) Compound Molecular weight (MW) Area % Reported activity References 1 20.098 2,5-bis(1,1-dimethylethyl) Phenol 206 21.11 Antifungal, Antioxidant, Antimicrobial [ 64 , 65 , 70 ] 2 16.433 Benzeneacetic acid 136 10.22 Antifungal, Antimicrobial [ 66 , 67 ] 3 24.217 1-Nonadecene 266 8.95 Antifungal, Antimicrobial [ 69 ] 4 28.123 Dibutyl phthalate 278 6.61 Antimicrobial [ 71 ] 5 26.933 7,9-Di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione 276 3.95 No reported antimicrobial This study 6 35.18 1-Heptacosanol 396 3.39 Antimicrobial, Antioxidant [ 72 ] 7 25.631 Phthalic acid, hex-3-yl isobutyl ester 320 2.72 No reported antimicrobial This study 8 24.725 Isopropyl myristate 270 2.37 Antimicrobial, Antioxidant [ 73 ] 9 40.539 Heptacosyl heptafluorobutyrate 592 1.51 No reported antimicrobial This study 10 39.928 Phthalic acid, di(2-propylpentyl) ester …”

Section: Resultsmentioning

confidence: 99%

Antimicrobial potentiality of actinobacteria isolated from two microbiologically unexplored forest ecosystems of Northeast India

et al. 2018

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BackgroundActinobacteria are often known to be great producers of antibiotics. The rapid increase in the global burden of antibiotic-resistance with the concurrent decline in the discovery of new antimicrobial molecules necessitates the search for novel and effective antimicrobial metabolites from unexplored ecological niches. The present study investigated the antimicrobial producing actinobacterial strains isolated from the soils of two microbiologically unexplored forest ecosystems, viz. Nameri National Park (NNP) and Panidehing Wildlife Sanctuary (PWS), located in the Eastern Himalayan Biodiversity hotspot region.ResultsA total of 172 putative isolates of actinobacteria were isolated, of which 24 isolates showed strong antimicrobial bioactivity. Evaluation of the ethyl acetate extracts of culture supernatants against test microbial strains revealed that isolates PWS22, PWS41, PWS12, PWS52, PWS11, NNPR15, NNPR38, and NNPR69 were the potent producers of antimicrobial metabolites. The antimicrobial isolates dominantly belonged to Streptomyces, followed by Nocardia and Streptosporangium. Some of these isolates could be putative novel taxa. Analysis of the antimicrobial biosynthetic genes (type II polyketide synthase and nonribosomal peptide synthetase genes) showed that the antimicrobial metabolites were associated with pigment production and belonged to known families of bioactive secondary metabolites. Characterization of the antimicrobial metabolites of Streptomyces sp. PWS52, which showed lowest taxonomic identity among the studied potent antimicrobial metabolite producers, and their interaction with the test strains using GC-MS, UHPLC-MS, and scanning electron microscopy revealed that the potential bioactivity of PWS52 was due to the production of active antifungal and antibacterial metabolites like 2,5-bis(1,1-dimethylethyl) phenol, benzeneacetic acid and nalidixic acid.ConclusionsOur findings suggest that the unexplored soil habitats of NNP and PWS forest ecosystems of Northeast India harbor previously undescribed actinobacteria with the capability to produce diverse antimicrobial metabolites that may be explored to overcome the rapidly rising global concern about antibiotic-resistance.Electronic supplementary materialThe online version of this article (10.1186/s12866-018-1215-7) contains supplementary material, which is available to authorized users.

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“…1,2,4-Benzothiadiazine heterocyclic ring system has been extensively investigated during the last 50 years, mainly because of its variety of biological activities, which includes diuretic (1), antihypertensive (2), potassium channel openers (3), a r adrenoreceptor antagonists (4), phosphodiesterase (PDE 4 ) inhibitors (5), free radical scavengers (6), allosteric modulators of AMPA/kainate receptors (7), bone regeneration (8), and prolylendopeptidase inhibitors (9). Structural similarity to other important pharmacophores, such as 4-quinazolinones (10) has recently impulse its preparation through modern combinatorial chemistry techniques (11).…”

Section: Introductionmentioning

confidence: 99%

“…for C, 3 H 10 Br 2 N 2 O 2 S:C, 37.34; H, 2.41; N, 6.70. Found: C, 37.15 ; H, 2.52 ; N,6.82.7-ChIoro-3-(3-chloro-phenyI)-3,4-dihydro-2Ä r -l,2,4-benzothiadiazine 1,1-dioxide (4b). Yield 82%.…”

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confidence: 99%

Synthesis and Preliminary Cytotoxic Evaluation of Novel 3,4-Dihydro-2h-1,2,4-Benzotiadiazine-1,1-Dioxide Derivatives

Restrepo¹,

Pérez²,

Salazar³

et al. 2006

Heterocyclic Communications

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Synthesis and free radical scavenging activity of 4-(2H-1,2,4-benzothiadiazine-1,1-dioxide-3-yl)-2,6-bis(1,1-dimethylethyl)phenols

Cited by 13 publications

References 16 publications

Interactive effects of marine heatwaves and eutrophication on the ecophysiology of a widespread and ecologically important macroalga

Interactive effects of marine heatwaves and eutrophication on the ecophysiology of a widespread and ecologically important macroalga

Antimicrobial potentiality of actinobacteria isolated from two microbiologically unexplored forest ecosystems of Northeast India

Synthesis and Preliminary Cytotoxic Evaluation of Novel 3,4-Dihydro-2h-1,2,4-Benzotiadiazine-1,1-Dioxide Derivatives

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