Synthesis and Fungicidal Activities of 2,3‐Dimethyl‐4‐(1‐acyloxy)alkoxy‐6‐tert‐butyl‐8‐fluoroquinolines

Abstract

A series of 2,3-dimethyl-4-(1-acyloxy)alkoxy-6-tert-butyl-8-fluoroquinolines were synthesized by 4-(tertbutyl)aniline as the starting material via acylation, substitution, and hydrolysis, and their structures were characterized by 1 H NMR, 13 C NMR, and HRMS. The fungicidal activity showed that compounds 6c, 6e, and 6f had excellent activity against Sphoaerotheca fuliginea with EC 50 values of 38.62, 6.77, and 50.35 mg/L, respectively. The results suggest that this chemotype of compounds warrant further studies as promising fungicide.