Synthesis and Fungicidal Activity against Rhizoctonia solani of 2-Alkyl (Alkylthio)-5-pyrazolyl-1,3,4-oxadiazoles (Thiadiazoles)

Abstract

Some series of 2-alkyl (alkythio)-5-((4-chloro)-3-ethyl-1-methyl-1H-pyrazole-5-yl)-1,3, 4-oxadiazoles (thiadiazoles) were prepared as potential fungicides. Their fungicidal activity was evaluated against rice sheath blight, which is a major disease of rice in China. Structure-activity relationships for the screened compounds were evaluated and discussed. It was found that 5-(4-chloro-3-ethyl-1-methyl-1H-pyrazole-5-yl)-1,3, 4-thiadiazole-2-thione has the higher fungicidal activity.

Separation of palmitic acid from over used oil for production of heterogeneous organic derivatives of potential biological activities

“…However elemental analysis and spectral data were in agreement only with the thiadiazine derivatives (12).Where compound 12 revealed 1 H NMR signals at δ 8.81 and 4.39 due to the two NH protons, moreover it exhibited a multiplate signal at δ 0.94-1.32 corresponding to an aliphatic protons. And its IR spectrum reveled two NH absorption bands at 3391 and 3310cm -1 , and other absorption band at ν 1653 cm -1 related to C=O function.…”

“…The solvent was then evaporated under reduced pressure; As a result a white solid crystal appeared. The crude solid was then filltered and recrystallized from DMF [29] to afford the corresponding product (12).…”

“…The structure elucidation of all synthesized compounds is based on the elemental analysis and spectral data (IR, 1 H NMR, 13 C NMR and MS). antifungal [12][13][14], antioxidant [15] and antidepressant [16 ].…”

Facile Synthesis and Antimicrobial Activities of 5H-[1,2,4]triazol[1,3,4]thiadiazine Derivatives

“…The 1,3,4-thiadiaznie derivatives in which 1,4-thiazines fused with 1,2,4-triazole nucleus are important scaffold in several natural and synthetic compounds of significant pharmacological properties and also have structural similarity with biologically most active phenothiazines in having fold along N-S axis 5 . These heterocycles have diverse applications as powerful antibacterial [6][7][8][9] , anti-mycobacterial 10,11 , antimitotic 12,13 , antifungal 14,15 , antidepressant 16,17 , analgesic 18 , anti-inflammatory, anticonvulsant 19 , antihypertensive 20 , antitumorial 21.22 , antiviral 23 , antiplatelet 24 and antithrombotic 25 .…”

An iodine-mediated green synthesis of 1,3,4-oxadiazoles under solvent-free conditions using grinding technique

“…1,3,4-Oxadiazoles are a known class of compounds, reported to exhibit antibacterial (1Á3), antifungal (4,5), analgesic and anti-inflammatory (6,7), anticonvulsant (8), hypoglycemic (9), and anticancer activities (10). These compounds are generally prepared by oxidative cyclization of N-acyl hydrazones prepared by the reaction of aromatic hydrazides with aromatic aldehydes.…”