Synthesis and fungicidal activity of novel strobilurin analogues containing substituted N-phenylpyrimidin-2-amines

Diversification Via Coupling Reactions and Biological Activities of Pyrimidine Derivatives

“…In 2009, Hui Chao Li and their colleagues synthesized a diverse set of new strobilurin analogs comprising substituted N-phenylpyrimidine-2-amines. [82] Numerous analytical methods, including HNMR, IR, and elemental analysis, were used to confirm the composition of these new compounds. To gauge their fungicidal effectiveness, the produced compounds underwent biological testing in a greenhouse.…”

Comprehensive Overview of β-Methoxyacrylate Derivatives as Cytochrome bc1 Inhibitors for Novel Pesticide Discovery

“…The most potent compound 33 showed more than 95% inhibition against CDM, WPM, and CA at 25 μg/mL, close to azoxystrobin. Specially, 33 displayed 100% inhibition against RB even at 0.92 μg/mL, which was superior to azoxystrobin (80%). , Zhang’s group prepared another two series of similar β-methoxyacrylate analogues. The lead compound 34 had IC 50 values of 9.9, 14.3, and 18.2 μg/mL in preventive treatment against Phytophthora capsici Leonian, Colletotrichum orbiculare , and B. cinerea Pers, respectively, more potent than those of control azoxystrobin (IC 50 = 15.9, 17.1, and 50.4 μg/mL) .…”

Design, synthesis and structure–activity relationship of novel insecticidal dichloro‐allyloxy‐phenol derivatives containing substituted pyrazol‐3‐ols

“…The intermediate derivatisation method (IDM) strategy has been proposed for the discovery of novel bioactive compounds in agrochemicals . Based on commercial availability and potentially promising activities of some known intermediates, totally novel structures are built with excellent bioactivity.…”