Synthesis and herbicidal activities of novel uracil derivatives containing pyrimidinyl moiety

He, Liping; Wu, Ying‐Ying; Zhang, Hanyun; Manyun, Liu; Shi, De‐Qing

doi:10.1007/s40242-014-3439-x

Cited by 1 publication

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“…8 Among the chemical families mentioned above, pyrimidinedione derivatives have attracted considerable attention in the field of agrochemistry during recent decades. 9 Butafenacil, 10 benzfendizone, 11,12 and saflufenacil 13 (Figure 1) are three representative commercialized pyrimidinedione type herbicides. Among them, butafenacil is a nonselective pre-emergence herbicide, derived from flupropacil by Syngenta in 1998, and has been successfully used for weed control in the field of vines, cotton, maize, and cereal crops.…”

Section: ■ Introductionmentioning

confidence: 99%

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Synthesis, Herbicidal Activity, and QSAR of Novel N-Benzothiazolyl- pyrimidine-2,4-diones as Protoporphyrinogen Oxidase Inhibitors

Zuo

et al. 2016

J. Agric. Food Chem.

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Protoporphyrinogen oxidase (PPO, E.C. 1.3.3.4) is known as a key action target for several structurally diverse herbicides. As a continuation of our research work on the development of new PPO-inhibiting herbicides, a series of novel 3-(2'-halo-5'-substituted-benzothiazol-1'-yl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4-diones 9 were designed and synthesized. The bioassay results indicated that a number of the newly synthesized compounds exhibited higher inhibition activity against tobacco PPO (mtPPO) than the controls, saflufenacil and sulfentrazone. Compound 9F-5 was identified as the most potent inhibitor with a Ki value of 0.0072 μM against mtPPO, showing about 4.2-fold and 1.4-fold higher potency than sulfentrazone (Ki = 0.03 μM) and saflufenacil (Ki = 0.01 μM), respectively. An additional green house assay demonstrated that compound 9F-6 (Ki = 0.012 μM) displayed the most promising postemergence herbicidal activity with a broad spectrum even at a concentration as low as 37.5 g of active ingredient (ai)/ha. Maize exhibits relative tolerance against compound 9F-6 at the dosage of 150 g ai/ha, but it is susceptible to saflufenacil even at 75 g ai/ha. Thus, compound 9F-6 exhibits the potential to be a new herbicide for weed control in maize fields.

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Section: ■ Introductionmentioning

confidence: 99%

“…Among the chemical families mentioned above, pyrimidinedione derivatives have attracted considerable attention in the field of agrochemistry during recent decades . Butafenacil, benzfendizone, , and saflufenacil (Figure ) are three representative commercialized pyrimidinedione type herbicides.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Herbicidal Activity, and QSAR of Novel N-Benzothiazolyl- pyrimidine-2,4-diones as Protoporphyrinogen Oxidase Inhibitors

Zuo

et al. 2016

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

Synthesis and herbicidal activities of novel uracil derivatives containing pyrimidinyl moiety

Cited by 1 publication

References 8 publications

Synthesis, Herbicidal Activity, and QSAR of Novel N-Benzothiazolyl- pyrimidine-2,4-diones as Protoporphyrinogen Oxidase Inhibitors

Synthesis, Herbicidal Activity, and QSAR of Novel N-Benzothiazolyl- pyrimidine-2,4-diones as Protoporphyrinogen Oxidase Inhibitors

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