Synthesis and Herbicidal Activity of 3-Aryl-5-(haloalkyl)-4-isoxazolecarboxamides and Their Derivatives

Chemistry of fluoro-substituted β-diketones and their derivatives

“…123 4-Phenyl-and 3-alkyl(aryl)-5-hydroxy-1-tosyl-5-trifluoromethyl-4,5-dihydro-1H-pyrazoles manifested antibacterial activity. 12 Pronounced pesticide properties were found for 3-aryl-5-trifluoromethylisoxazoles, 301 3-aryl-5-(chlorodifluoromethyl)-4-isoxazolecarboxamides and their derivatives 302,303 Antibacterial activity was found for 3-aryl-5trifluoromethylpyrazoles. 137 1,5-Diaryl-3-difluoromethyl-and -3-trifluoromethylpyrazoles containing substituted benzenesulfonamide or azidophenyl residues as pharmacophores comprise a family of selective inhibitors of cyclooxygenase-2 (Refs 129, 304 ± 306).…”

Synthesis of bromodifluoromethyl substituted pyrazoles and isoxazoles

“…Many examples have been reported on the synthesis of trifluoromethyl substituted pyrazoles and isoxazoles, and such compounds have found their applications in medicine and agriculture [11]. However there are limited examples on the synthesis of halodifluoromethyl substituted heterocyles, especially pyrazoles and isoxazoles [11,12]. Prabhakaran et al [11] and Talley et al [13] described the synthesis of bromodifluoromethyl and chlorodifluoromethyl substituted pyrazoles from corresponding b-diketones and hydrazine derivatives respectively, however, both in low yields.…”

“…Prabhakaran et al [11] and Talley et al [13] described the synthesis of bromodifluoromethyl and chlorodifluoromethyl substituted pyrazoles from corresponding b-diketones and hydrazine derivatives respectively, however, both in low yields. Halodifluoromethyl pyrazoles or isoxazoles may have potential biological activities [12,14]. They also would be very useful starting materials to build new difluoromethylated pyrazoles or isoxazoles by the displacement of bromine [15][16][17][18][19][20][21].…”

Synthesis and growth regulatory activity of pyrazolesulfanyl‐ and isoxazolesulfanyl‐1H‐[1,2,4]triazoles and their azinyl derivatives

“…Among the pyrazole and isoxazole derivatives the substances with herbicidal [4–14], fungicidal [15–20], and insecticidal [21–25] activity were also revealed. However, the number of these preparations is incomparably smaller than the chemical means of plant protection with triazole, triazine, pyrimidine, thiadiazole, and thiazole cycles [1].…”