Synthesis and Herbicidal Activity of Novel<i>N</i>-Hetrocyclo Containing Nitrogen Methoxy-<i>O</i>-(4-aryloxy-phenyl) Lactamide Derivatives

刘祈星,; 黄明智,; 柳爱平,; 聂思桥,; 雷满香,; 任叶果,; 裴晖,; 何丽英,; 胡礼,; 胡艾希,

doi:10.6023/cjoc201307017

Cited by 7 publications

(1 citation statement)

References 3 publications

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“… On the other hand, most of the commercial APP herbicides are in the form of formulated ester, providing more lipophilicity and increased capacity to cross cellular membranes. Meanwhile, many studies prove that delicate modification of the ester moiety of phenoxypropionate part of APP herbicides can improve herbicidal activity. − Inspired by this, as a continuation of the development of new QPP derivatives with stronger herbicidal activity, great effort has been made to modify the ester moiety of lead compound QPP-I in our laboratory. First, replacing the ethoxy group of ester moiety of the lead compound QPP-I with various alcohols and phenols, QPP - I ester derivatives were designed.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Herbicidal Activity, and Molecular Mode of Action Evaluation of Novel Aryloxyphenoxypropionate/Amide Derivatives Containing a Quinazolinone Moiety

Li,

Chen,

Han

et al. 2024

J. Agric. Food Chem.

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To develop aryloxyphenoxypropionate herbicides with a novel structure and improved activity, a total of 39 aryloxyphenoxypropionate/amide derivatives containing quinazolinone moiety were synthesized and further bioevaluated. The bioassay results in the greenhouse showed that most of the target compounds had good herbicidal activity under postemergence conditions, of which, QPP-I-6 displayed excellent herbicidal activity against Echinochloa crusgalli, Digitaria sanguinalis, Spartina alterniflora, Eleusine indica, and Pennisetum alopecuroides with inhibition rates >90% at a dosage of 187.5 g ha −1 . More importantly, QPP-I-6 displayed higher crop safety to Gossypium hirsutum, Glycine max, and Arachis hypogaea than the commercial herbicide quizalofop-p-ethyl. Studying the molecular mode of action by phenotypic observation, membrane permeability evaluation, transcriptomic analysis, and in vivo ACCase activity evaluation reveals that QPP-I-6 is a novel ACCase inhibitor. The present work demonstrates that QPP-I-6 can serve as a lead compound for further developing novel ACCase-inhibiting herbicides.

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