Synthesis and herbicidal potential of substituted aurones

Abstract

It is possible that aurone derivatives, which possess structures different from those of the commercial herbicides, may become novel lead compounds for the development of herbicides against dicotyledonous weeds with further structure modification.

Synthesis and Biological Activities of 6‐Hydroxyaurone Derivatives

“…When the phenyl ring B was replaced by a furan ring, the resulted molecule ( 2j ) showed a low herbicidal activity against B . campestris at 100 µg·mL −1 , which is consistent with that of 4,6‐dimethoxyaurones . In an effort to study the function of 6‐hydroxyl group, modification of 6‐hydroxyl group by alkylation with 1‐chloroacetone was carried out.…”

“…crus‐galli ). The results revealed that 6‐hydroxyaurones possessed the same selectivity as 4,6‐dihydroxyaurones, but showed slightly lower herbicidal activity than the latter .…”

“…However, there are few reports concerning the herbicidal activity of aurones with a substituent only on 6‐position of ring A, especially with a 6‐hydroxyl group . To continue our study on the ornamentation of aurone , herein we describe the synthesis, structural characterization, and herbicidal evaluation of 6‐hydroxyaurone derivatives, as well as their antiproliferative activity against human liver carcinoma (HepG‐2), cervix epithelioid carcinoma (HeLa), and breast cancer cell line (MCF‐7).…”

Synthesis and anti-cancer activity evaluation of new aurone derivatives

“…Aurones, (Z)-2-benzylidenebenzofuran-3-(2H)-ones ( Figure 1c), constitute a less studied subclass of flavonoids although they are isosteres of flavones 5,6 . However, they have attracted attention with promising biological potential such as anti-microbial 7 , anti-cancer 8 , anti-leishmanial [9][10][11] , anti-histaminic 12 , antiinflammatory 13 , antioxidant 14 , insect anti-feedant 15 , herbicidal 16 , anti-HIV 17,18 , anti-HCV (hepatis C virus) 19,20 , anti-malarial 21,22 , ChE inhibitory 23,24 , MAO inhibitory 25 activities in the specified studies. The observed biological potential is thought to be due to the similarity of adenine of ATP and the flavonoids, consequently inhibition of the activity of ATP-dependent enzymes and proteins, which is essential for the function of enzymes and receptors.…”

An Aurone‐derived Low‐molecular‐weight Fluorescence Probe for the Detection of Hg2+ in Aqueous Solution and Living Cells

“…Aurones (2‐benzylidenebenzofuran‐3(2 H )‐ones), as isomers of flavones, are naturally occurring yellow pigments from plants. They demonstrate a great diversity of biological activities, including antimicrobial , anticancer , antiviral , antifungal , and herbicidal activities. It was also reported that aurone derivatives could serve as fluorescent probes to detect CN − and biomacromolecules .…”