Synthesis and hypoglycemic and anti-inflammatory activity of metal complexes of 4-aryl-2-hydroxy-4-oxo-2-butenoic acid N-heterylamides

Пулина, Н. А.; Собин, Ф. В.; Краснова, А. И.; Yushkova, T. A.; Yushkov, V. V.; Мокин, П. А.; Yatsenko, K. V.; Бабушкина, Е. Б.

doi:10.1007/s11094-011-0615-x

Cited by 3 publications

(1 citation statement)

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“…On the other hand, the increasing interest of researchers for chemical modification of biologically active compounds by complexation with various metals is noteworthy . New therapeutic strategies based on agents sharing antioxidant, anti‐microbial and anti‐inflammatory properties should be helpful to counter the development of chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

Catalytic and biological valorization of a supramolecular mononuclear copper complex based 4‐aminopyridine

Hfidhi

Bkhairia

Atoui

et al. 2019

Applied Organom Chemis

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Hydrothermal reaction of copper bromide with 4‐aminopyridine in DMF solution yields a new mononuclear copper complex [Cu(C5H6N2)4]2Br.2(C3H7NO) abbreviated Cu‐4AP‐Br. The product was characterized, structurally, by single‐crystal X‐ray diffraction analysis and, thermally, by DSC‐ATG measurement. The inorganic–organic hybrid compound Cu‐4AP‐Br crystallizes in the centrosymmetric space group Pbcn, exhibiting a supramolecular network. Simultaneous DSC‐ATG analysis shows that this compound remains stable up to 100 °C and then performs a successive decompositions accompanied with endothermic peaks. The complex Cu‐4AP‐Br was applied as a catalyst in the Heck coupling reaction under ultrasonic irradiation in various reaction conditions. The yields, obtained for a short period of time, allow us to consider this complex, generating selectivity on the external position of styrene with a preference of the trans form over cis, as an excellent catalyst for this type of reaction. Interestingly, Cu‐4AP‐Br displayed important antibacterial (Gram‐positive and Gram‐negative) and antioxidant activities (β‐carotene bleaching inhibition, scavenging effect on DPPH free radical, and reducing power).

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Section: Introductionmentioning

confidence: 99%