Synthesis andin vitroactivity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line

Abstract

This paper presents a method for synthesis and cytotoxicity of new platinum(II) complexes of (9′-fluorene)-spiro-5-hydantoin (L1) and (9′-fluorene)-spiro-5-(2-thiohydantoin) (L2). The new obtained complexes were studied by elemental analysis: ultraviolet–visible, attenuated total reflection Fourier transform infrared (ATR-FTIR), and 1H- and 13C-NMR for Pt(II) compounds and additionally Raman spectroscopy for free ligands. Based on the experimental data, the most probable structure of the complexes is suggested. In the present study, we have examined cytotoxic activity of (9′-fluorene)-spiro-5-hydantoin (L1) and (9′-fluorene)-spiro-5-(2-thiohydantoin) (L2) and their Pt(II) complexes on the retinoblastoma cell line WERI-Rb-1.

Synthesis and antimicrobial study of new Pt(IV) and Ru(III) complexes of fluorenylspirohydantoins

“…Only the Raman spectra of the free ligands HL1 and HL2 were measured and cited in our previous paper. 29 The two vibrational (N 1 -H) and (N 3 -H) stretching modes did not appear in the Raman spectra of (9'-fluorene)-spiro-5hydantoin (HL1) and (9'-fluorene)-spiro-5-(2thiohydantoin) (HL2). In the IR spectrum of HL1 the bands at 1776 cm −1 and 1718 cm −1 can be attributed to stretching vibrations of C 4 =O and C 2 =O groups of the hydantoin ring.…”

“…In the studies cited above, we have investigated cytotoxic activities of the two compounds on the retinoblastoma cell line WERI-Rb-1 and antibacterial effects towards Gram-positive, Gram-negative bacteria, as well as yeasts C. albicans. Recently, we studied the complexation properties of (9'-fluorene)spiro-5-hydantoin and its 2-thio derivative with Pt(II) 29 and Cu(II) 30 , as well as we reported the synthesis and structural characterization of new Cu(II) and Ni(II) complexes of (9'-fluorene)-spiro-5dithiohydantoin. 31 The two Pt(II) complexes show significant effects on cancer cell growth compared to their ligands.…”

New platinum(II) complexes of cycloalkanespiro-5-(2-thiohydantoins). Synthesis and quantum chemical investigation

“…In another previous paper of ours, we have described a method for synthesis, examination of cytotoxicity and antibacterial effects of 3-amino-9'-fluorenespiro-5-hydantoin 30 and new Pt(II) complexes of (9'-fluorene)-spiro-5-hydantoin and its 2-thio derivative. 31 The two platinum complexes show significant effects on cancer cell growth compared to their ligands. Recently, we studied the complexation properties of cyclohexanespiro-5-(2,4-dithiohydantoin) with copper and nickel.…”

Study on the Synthesis, Characterization and Bioactivities of 3-Methyl-9’-fluorenespiro-5-hydantoin

“…57 Fluorenylspirohydantoins have a good ability to coordinate metal ions. Copper(II) and nickel(II) complexes of (9'-fluorene)-spiro-5-dithiohydantoin, 58 as well as platinum(II) complexes of (9'-fluorene)-spiro-5-hydantoin and (9'-fluorene)-spiro-5-(2-thiohydantoin) 59 have been described in this aspect. Moreover, we reported studies about synthesis, cytotoxicity and antibacterial activity of some fluorenylspirohydantoin derivatives [60][61][62] and their platinum(II) complexes.…”

“…Moreover, we reported studies about synthesis, cytotoxicity and antibacterial activity of some fluorenylspirohydantoin derivatives [60][61][62] and their platinum(II) complexes. 59 Recently, we discussed the synthesis, characterization and quantum chemical investigation of new Pt(II) complexes of cyclohexanespiro-5-(2-thiohydantoin) and cycloheptanespiro-5-(2-thiohydantoin). 63 In our previous works we reported a method for synthesis, cytotoxicity and antibacterial activity of 3-amino-9'-fluorenespiro-5-hydantoin.…”