Synthesis and <i>in vitro</i> and <i>in vivo</i> anti-inflammatory activity of novel 4-ferrocenylchroman-2-one derivatives

Guo, Weiyun; Chen, Liuzeng; Shen, Bang-Nian; Liu, Xinhua; Tai, Guihua; Liu, Qingshan; Gao, Li; Ruan, Ban‐Feng

doi:10.1080/14756366.2019.1664499

Cited by 13 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To establish an arthritis model, we used Freund’s complete adjuvant to induce arthritis in rats via injection of CFA into the left hind paw of rats 53 , 54 . After injection of CFA into SD rats, the results showed that 80–90% of the rats showed paw swelling within 14–28 days ( Figure 6 , model group).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and anti-rheumatoid arthritis activities of 3-(4-aminophenyl)-coumarin derivatives

Miao

Yang

Yun

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

Rheumatoid arthritis is a chronic systemic disease characterised by an unknown aetiology of inflammatory synovitis. A large number of studies have shown that synoviocytes show tumour-like dysplasia in the pathological process of RA, and the changes in the expression of related cytokines are closely related to the pathogenesis of RA. In this thesis, a series of novel 3-(4-aminophenyl) coumarins containing different substituents were synthesised to find new coumarin anti-inflammatory drugs for the treatment of rheumatoid arthritis. The results of preliminary activity screening showed that compound 5e had the strongest inhibitory activity on the proliferation of fibroid synovial cells, and it also had inhibitory effect on RA-related cytokines IL-1, IL-6, and TNF-α. The preliminary mechanism study showed that compound 5e could inhibit the activation of NF-κB and MAPKs signal pathway. The anti-inflammatory activity of compound 5e in vivo was further determined in the rat joint inflammation model.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis and anti-rheumatoid arthritis activities of 3-(4-aminophenyl)-coumarin derivatives

Miao

Yang

Yun

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

show abstract

“…As a kind of the proinflammatory mediator, NO participates in many kinds of inflammatory reactions . Therefore, it has been established that the ability of compounds to inhibit NO overproduction could be used to assess anti-inflammatory effects. − As shown in Figure d, the production of NO of LPS-treated RAW264.7 cells remarkably increased six times compared with that of control cells. In the absence of LPS stimulation, the Rhein solution group showed no effect on NO secretion.…”

Section: Resultsmentioning

confidence: 99%

Self-Assembled Herbal Medicine Encapsulated by an Oxidation-Sensitive Supramolecular Hydrogel for Chronic Wound Treatment

Zhao

Zhang

et al. 2020

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Inflammation has been assumed to affect the pathology of wound healing and is associated with many nonhealing chronic wounds. Naturally derived herbal medicines with anti-inflammatory properties are of interest because of their effectiveness and affordability in clinical treatment. Herein, we report a supramolecular hydrogel comprising self-assembled natural herb rhein and an oxidative responsive cross-linked network based on ferrocene and β-cyclodextrin host–guest recognitions. Rhein can directly self-assemble into fibrils, exerting better anti-inflammation efficiency than its free drug form. The adaption of the supramolecular network can greatly improve the stability and retain the structural integrity of encapsulated self-assembled rhein. In addition, host–guest recognition confers dissolution of the hydrogel under oxidative stress, thereby delivering self-assembled rhein to the wound site and exerting better therapeutic efficiency. Evaluations in diabetic mice indicate that the resultant hydrogel promoted chronic wound healing by suppressing excess reactive oxygen species, facilitating the transition of the wound healing process, and restoring the normal wound-repair process. Therefore, the proposed hydrogel has a potential value as an herbal-based dressing for future clinical chronic wound management.

show abstract

“…The design and synthesis of some novel anti‐inflammatory 4‐ferrocenylchroman‐2‐one derivatives (Scheme 19) for the treatment of arthritis was reported by Guo et al [ 59 ] The screening of the compounds was performed to determine the anti‐inflammatory effect by inhibition of LPS induced NO production in RAW 264.7 macrophages. The SAR was also developed and it was found that NO inhibitory activity increases on introducing coplanar groups like naphthalenyl ( 24 ) (Figure 15) and benzodioxol bridging to the dihydrocoumarin ring.…”

Section: Development Of Antiarthritic Agents So Farmentioning

confidence: 99%

Therapeutic management of arthritis: A review on structural and target‐based approaches

Mahore

Kamboj

Kaleem

et al. 2022

Archiv der Pharmazie

View full text Add to dashboard Cite

Inflammation is the natural defense mechanism against any external stimuli in the human body and it saves us from foreign entities that may alter our bodies' normal functioning. Any anomaly in this natural defense system leads to the development of different pathological conditions associated with chronic inflammation like rheumatoid arthritis, osteoarthritis, atopy, asthma, allergic rhino-conjunctivitis, coronary artery disease, cardiac arrhythmias, obesity, insulin resistance and type-2 diabetes, depression, and aging. These disorders impair the quality of life of affected people in different ways. Among these, rheumatoid arthritis and osteoarthritis are the most common chronic inflammation-associated disorders. Different therapeutic strategies are already available for the treatment of rheumatoid arthritis and osteoarthritis, but all with pros and cons. Here, we discuss the emergence of several antiarthritic analogs developed by different researchers which could provide the basis for the evolution of newer therapeutic strategies with better activity and safety profiles.

show abstract

Synthesis and in vitro and in vivo anti-inflammatory activity of novel 4-ferrocenylchroman-2-one derivatives

Cited by 13 publications

References 28 publications

Synthesis and anti-rheumatoid arthritis activities of 3-(4-aminophenyl)-coumarin derivatives

Synthesis and anti-rheumatoid arthritis activities of 3-(4-aminophenyl)-coumarin derivatives

Self-Assembled Herbal Medicine Encapsulated by an Oxidation-Sensitive Supramolecular Hydrogel for Chronic Wound Treatment

Therapeutic management of arthritis: A review on structural and target‐based approaches

Contact Info

Product

Resources

About