Synthesis and In Vitro Urease Inhibition of Some Novel Benzimidazole‐based Hydrazones

Abstract

A novel series of N′‐(substituted benzylidene)‐2‐(5,6‐dichloro‐2‐methyl‐1H‐benzimidazol‐1‐yl)acetohydrazides and N′‐(1‐(substituted phenyl)ethylidene)‐2‐(5,6‐dichloro‐2‐methyl‐1H‐benzimidazol‐1‐yl)acetohydrazides were synthesized and then studied for their urease inhibitory activities using thiourea as a standard drug. All newly synthesized compounds were found to exhibit potent inhibitory properties against urease enzyme in the range of IC50 = 0.0155 ± 0.0039–0.0602 ± 0.0071 μM, when compared with the thiourea as standard (IC50 = 0.5115 ± 0.0233 μM). All target molecules were characterized by 1H‐NMR, 13C‐NMR, IR, and electrospray ionization mass spectrometry.

Synthesis and Antibacterial Activity of New Azole, Diazole and Triazole Derivatives Based on p-Aminobenzoic Acid

“…This is because of the compounds, which have an arylidene hydrazide structure. The restricted rotation around the CO−NH bond causes the formation of a mixture of Z/E rotamers, whereas the presence of a double bond of CH=N influences the formation of geometric isomers, which are clearly visible in the spectra of these compounds [ 74 ]. The ratio in each case was calculated by using 1 H-NMR data, and they are as follows: 0.75:0.25 for a – c , e and 0.8:0.2 for d .…”