Synthesis and Identification of A Novel Fentanyl Analog

Abstract

In the background of the growing popularity of synthetic opioids in the field of narcotics, this study explores the synthesis and identification of a novel fentanyl analog, trifluoromethyl fentanyl (TFMF). Utilizing advanced analytical techniques for qualitative analysis, such as NMR Spectroscopy, LC and GC-MS. The synthesis process highlights the method starting with N-tert-butoxycarbonyl-4-piperidone with a final product yield of 53%. Characterization through 1H-NMR reveals the successful incorporation of the trifluoromethyl group into the fentanyl structure. Liquid chromatography and melting point analysis confirms the high purity of the synthesized compound. GC-MS analysis provides essential qualitative data, identifying characteristic ion peaks that uniquely define TFMF. This study adds to existing knowledge of novel fentanyl analogues and highlights the importance of analytical techniques in addressing the opioid crisis.