Synthesis and Identification of New Heterocyclic Compounds from Isatin by Schiff Base Reaction

Abstract

Heterocyclic compounds possess a cyclic structure with two or more different kinds of atoms in the ring. The history of heterocyclic chemistry began in the 1800s, in step with the development of organic chemistry. Since rings can be of any size, from three-membered upwards, and since the heteroatoms can be drawn in almost any combination from a large number of the elements (though nitrogen, oxygen, and sulfur are still by far the most common), the number of possible heterocyclic systems is almost limitless. An enormous number of heterocyclic compounds are known and this number continues to increase very rapidly. This work is divided into two different parts: First part: Synthesis of imines by Schiff base reaction, this part involves synthesis three of imines by treatment isatin with a variety of cyclo primary amines. Second part: [3 + 2] Cycloaddition reaction, this part includes reacting each product of the first part with two types of amino acids. All steps of reactions followed by TLC– papers. All synthesized compounds were confirmed through the use of different spectroscopic techniques (IR and NMR), melting points.

Synthesis, Characterization of some new Heterocyclic Compounds Derived from Chalcones Containing Schiff Bases

“…Chalcones are considered as flavonoid compounds which have therapeutic effects in a range of biological activities as anti-cancer (Elkanzi et al, 2022), anti-oxidant (Tiwari et al, 2021, and anti-inflammatory (Salehi et al, 2021). Schiff bases are prepared from the condensation of aldehydes and ketones with primary amines (R-NH2) and were discovered by the German scientist (Schiff), who first attended them in 1864 and named after him (Alfatlawi et al, 2022). The biological efficacy of Schiff bases has been evaluated and demonstrated efficacy, against many cancer diseases, anti-microbial (Venkateswarlu et al, 2022), anti-tuberculosis (Jameel and Sheat, 2013), anti-AIDS (Kar et al, 2022).…”