Synthesis and identification of β-aryloxyquinoline based diversely fluorine substituted N-aryl quinolone derivatives as a new class of antimicrobial, antituberculosis and antioxidant agents

Crystal structure of 4-(3-Methoxy-phenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester, C22H27NO4

“…Recognizing the considerable importance of the compounds, research focused on the synthesis of new 4-arylpolyhydroquinoline [3,4]. In the crystal structure of the title compound, the sixmembered ring containing a nitrogen atom is obviously folded.…”

Novel 1,3,4-oxadiazole motifs bearing a quinoline nucleus: synthesis, characterization and biological evaluation of their antimicrobial, antitubercular, antimalarial and cytotoxic activities

“…The in vitro antimicrobial screening of targeted compounds 8al at minimal inhibitory concentration (MIC) in millimolar (mM) were carried out by broth micro dilution method according to National Committee for Clinical Laboratory Standards (NCCLS) [37][38][39] Table 3.…”

“…Primary screening of targeted compounds 8a-l were performed at 250 µg/mL against Mycobacterium tuberculosis H37Rv strain using Lowenstein-Jensen medium (conventional method) as described by Rattan [38][39][40] . Primary screening of targeted compounds 8a-l were performed at 250 µg/mL against Mycobacterium tuberculosis H37Rv strain using Lowenstein-Jensen medium (conventional method) as described by Rattan [38][39][40] .…”

Synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives: assessment of their antimicrobial, antituberculosis and antioxidant activity

“…Thus, in view of the biological significance of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione, a modification on the 1-position of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione by 3-methyl-5-phenoxy-1-phenyl-1H-pyrazole was undertaken to check whether it brings significant changes in the bioactivities of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives. As a part of our current study in developing new antimicrobial agents via combination of two therapeutically active moieties [22][23][24][25], we report herein the C. B. Sangani et al preparation 1H-pyrazolo[1,2-b]phthalazine-5,10-dione 4a-p derivatives by an MCR approach.…”

“…In continuation of our interest on synthesizing biologically potent antimicrobials [22][23][24][25], we report herein a new series of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione derivatives (4a-p) via one-pot, three-component base-catalyzed cyclo condensation reaction of 3-methyl-5-aryloxy-1-aryl-1H-pyrazole-4-carbaldehyde (1a-d), malononitrile or ethyl cyanoacetate (2a-b) and 2,3-dihydro-1,4-phthalazinedione (3a-b) in ethanol containing eco friendly base NaOH in good to excellent yields (Scheme 1). The required starting material, 1-aryl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde was prepared by using the procedure in the literature [26].…”