Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins

Meng, Xiangxi; Yang, Dachuan; Keyvan, Golshid; Michniak‐Kohn, Bozena; Mitra, Somenath

doi:10.1016/j.colsurfb.2011.11.043

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…Figure 8 shows that the amount of HPC adsorbed was much higher in the presence of SDS for all drugs potentially due to the co-adsorption of SDS with HPC and the facilitation of HPC adsorption by SDS 20,22 . The co-adsorbed layers can impart electrosteric stabilization to the GF particles ( Figure 1c); a sufficiently thick stabilizer layer on drug particle surfaces provides a sufficiently high steric barrier to mitigate aggregation along with electrostatic charges 23,25 . Despite such possible advantages of higher amount of adsorption and associated lower d 90 and improved stability for AZD, the AZD suspensions had d 90 values greater than 1 mm because the coarse particles in the suspensions were mostly plate-like crystals (coarsely broken crystals), not solely aggregates of smaller primary particles.…”

Section: Hpc-sds Synergistic Stabilizationmentioning

confidence: 99%

“…In electrostatic stabilization, the surfaces of the particles are charged so that repulsion forces are created, which can overcome the attractive Van der Waals forces between the particles. However, particles of most drugs are not inherently charged 25 ; hence, surface charges typically originate from adsorbed anionic surfactants and/or ionic polymers ( Figure 1). Steric stabilization results from the adsorption of polymers onto the surface of the particles.…”

Section: Introductionmentioning

confidence: 99%

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Is the combination of cellulosic polymers and anionic surfactants a good strategy for ensuring physical stability of BCS Class II drug nanosuspensions?

Bilgili

Afolabi

2015

Pharmaceutical Development and Technology

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Ensuring the physical stability of drug nanosuspensions prepared via wet media milling has been a challenge for pharmaceutical scientists. The aim of this study is to assess the combined use of non-ionic cellulosic polymers and anionic surfactants in stabilizing multiple drug nanosuspensions. Particle size of five drugs, i.e. azodicarbonamide (AZD), fenofibrate (FNB), griseofulvin (GF), ibuprofen (IBU) and phenylbutazone (PB) was reduced separately in an aqueous solution of hydroxypropyl cellulose (HPC) with/without sodium dodecyl sulfate (SDS) via a stirred media mill. Laser diffraction, scanning electron microscopy, thermal analysis, rheometry and electrophoresis were used to evaluate the breakage kinetics, storage stability, electrostatic repulsion and stabilizer adsorption. Without SDS, drug particles exhibited aggregation to different extents; FNB and GF particles aggregated the most due to low zeta potential and insufficient steric stabilization. Although aggregation in all milled suspensions was reduced due to HPC-SDS combination, FNB and IBU showed notable growth during 7-day storage. It is concluded that the combination of non-ionic cellulosic polymers and anionic surfactants is generally viable for ensuring the physical stability of wet-milled drug nanosuspensions, provided that the surfactant concentration is optimized to mitigate the Ostwald ripening, whereas cellulosic polymers alone may provide stability for some drug suspensions.

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Section: Hpc-sds Synergistic Stabilizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is the combination of cellulosic polymers and anionic surfactants a good strategy for ensuring physical stability of BCS Class II drug nanosuspensions?

Bilgili

Afolabi

2015

Pharmaceutical Development and Technology

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“…The advantage of HP‐CDs was illustrated for the CD/Griseofulvin (GF) complex. Although β‐CDs and Me‐β‐CDs were as effective in stabilizing the drug suspensions and reducing the size of drug nanoparticles, HP‐β‐CD showed the highest efficacy (Meng, Yang, Keyvan, Michniak‐Kohn, & Mitra, ).…”

Section: Oligosaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

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Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple monoor disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based nanoparticles and nanogels were used for drug delivery, imaging, and tissue engineering applications. Due to the reversible nature of the assembly, often based on a combination of hydrogen bonding and hydrophobic interactions, carbohydrate-based materials are valuable substrates for the creations of responsive systems. Herein, we review the current research on carbohydratebased nanomaterials, with a particular focus on carbohydrate assembly. We will discuss how these systems are formed and how their properties are tuned. Particular emphasis will be placed on the use of carbohydrates for biomedical applications.

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“…It was reported that during the formation of the complex, HP-β-cyclodextrin could effectively inhibit the particle growth and stabilize the suspensions; in total, 72% of the griseofulvin was precipitated, while the rest of the griseofulvin formed the inclusion complex. The mixture showed improvements in the release rate and water solubility by 9.9 and 11.5 times, respectively [21][22][23]. When the solution of griseofulvin in the mixture of acetone and ethanol was treated with β-cyclodextrin, griseofulvin submicron particles from 600 to 900 nm were obtained and showed marked improvement in dissolution velocity [5].…”

Section: Introductionmentioning

confidence: 99%

Solubility and Pharmacokinetic Profile Improvement of Griseofulvin through Supercritical Carbon Dioxide-Assisted Complexation with HP-γ-Cyclodextrin

Ding,

Cui,

Zhang

et al. 2023

Molecules

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Since griseofulvin was marketed as a non-polyene antifungal antibiotic drug in 1958, its poor water solubility has been an issue for its wide applications, and over the last sixty years, many attempts have been made to increase its water solubility; however, a significant result has yet to be achieved. Through supercritical carbon dioxide-assisted cyclodextrin complexation with the addition of a trace amount of water-soluble polymer surfactant, the griseofulvin inclusion complex with HP-γ-cyclodextrin was prepared and confirmed. The 1:2 ratio of griseofulvin and HP-γ-cyclodextrin in the complex was determined based on its NMR study. After complexation with HP-γ-cyclodextrin, griseofulvin’s water solubility was increased 477 times compared with that of griseofulvin alone, which is the best result thus far. The complex showed 90% of griseofulvin release in vitro in 10 min, in an in vivo dog pharmacokinetic study; the Cmax was increased from 0.52 µg/mL to 0.72 µg/mL, AUC0–12 was increased from 1.55 μg·h/mL to 2.75 μg·h/mL, the clearance was changed from 51.78 L/kg/h to 24.16 L/kg/h, and the half-life time was changed from 0.81 h to 1.56 h, indicating the obtained griseofulvin complex can be a more effective drug than griseofulvin alone.

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Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins

Cited by 5 publications

References 41 publications

Is the combination of cellulosic polymers and anionic surfactants a good strategy for ensuring physical stability of BCS Class II drug nanosuspensions?

Is the combination of cellulosic polymers and anionic surfactants a good strategy for ensuring physical stability of BCS Class II drug nanosuspensions?

Carbohydrate‐based nanomaterials for biomedical applications

Solubility and Pharmacokinetic Profile Improvement of Griseofulvin through Supercritical Carbon Dioxide-Assisted Complexation with HP-γ-Cyclodextrin

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