Synthesis and in silico screening of novel 2-methylquinoline-4-ones bound with the pyrazol-5-ones moiety

Abstract

-метил-3-[(5-оксо-4,5-дигидро-1H-пиразол-4-ил)

Synthesis and the antimicrobial activity of 3-(2-methyl-4-oxo-1,4-dihydroquinoline-3-yl)propanoic acids

“…Ethyl 2-((2-methyl-4-oxo-1,4-dihydroquinolin-3-yl)methyl)-3-oxobutanoate 7 was obtained using the method previously described [14]. thyl-2-methyl-1,4-dihydroquinoline-4-one as a versatile alkylating agent.…”

“…As the starting material 3-dimethylaminomethyl-2-methyl-1,4-dihydroquinoline-4-one 1 was used, its quaternization with methyl iodide allowed to obtain an effective alkylating agent [13,14]. Тhe alkylation of malonic (ii) and acetoacetic ester (vii) was performed to form compounds 2a-c and 7 without further isolation 1 from the reaction medium.…”