Synthesis and in vitro antitumour evaluation of benzothiazole-2-carbonitrile derivatives

Synthesis, characterization and evaluation of antibacterial activity of some thiazolo[3,2-b][1,2,4]triazole incorporating diphenylsulfone moieties☆

“…The proposed mechanism of formation of thiazolo-triazoles 6 and 7 (Scheme 2) from S-alkylated 1,2,4-triazoles 4 and 5, in acidic media, The structural assignments of the new compounds were based on their elemental analysis and spectral (IR, 1 H NMR, 13 C NMR and MS) data. The characterization data of all the new compounds are summarized in Table 1.…”

“…Compounds containing 1,2,4-triazole nucleus exhibit antibacterial [1][2][3], antifungal [1,4,5], anti-tubercular [6], antiinflammatory [7,8], activities. The thiazole nucleus is also present in various molecules with diverse pharmacological properties, such as antimicrobial [9][10][11], anti-inflammatory [12], antitumoral [13].…”

Solid-Phase Synthesis of 2-Arylbenzothiazole Using Silica Sulfuric Acid under Microwave Irradiation

“…Benzothiazole and their derivatives are very important groups of heterocyclic compounds, 1 and are well known for their biological and pharmaceutical activities, such as antimicrobial, 2 antiglutamate/antiparkinsonism agents 3 and antitumour, 4 which exhibit nanomolar inhibitory activity against a range of human breast, ovarian, colon and renal cell lines in vitro. In addition, they represent one of the most promising antiamyloid therapies for treatment of a number of a heterogeneous family of diseases referred to generically as amyloidosis, including Alzheimer's disease (AD), type II diabetes, variant Creutzfeldt-Jakob disease, painful joints associated with long term hemodialysis and rare cases of hereditary insomnia.…”

Synthesis and identification of a new class of (S)-2,6-diamino-4,5,6,7-tetrahydrobenzo[d]thiazole derivatives as potent antileukemic agents

“…In this respect, the benzothiazole constitutes an important scaffold of drugs, possessing several pharmacological functions. The interesting anticancer properties of these compounds take the initiative of synthesis and anticancer studies of many new benzothiazole derivatives [11][12][13][14][15]. In addition, these derivatives are used as neurotransmission blocker [16][17][18], calmodulin (CaM) antagonists [19] and neuroprotective agent [20,21].…”