Synthesis and in vitro biology of Co(II), Ni(II), Cu(II) and Zinc(II) complexes of functionalized beta-diketone bearing energy buried potential antibacterial and antiviral O,O pharmacophore sites

Crystal structure of (Z)-1-(1,5-dimethyl-1H-pyrazol-3-yl)-3-hydroxy-3-(4-methoxyphenyl)prop-2-en-1-one, C15H16N2O3

“…Some heterocyclic compounds bearing β-keto-enol functionality have recently attracted a great attention due to their applications in organic and inorganic chemistry [1][2][3][4]. In this work we coupled ethyl pyrazole carboxylate with pOMe-phenyl methyl ketone to produce the title compound in acceptable yield.…”

β-Keto-enol Tethered Pyridine and Thiophene: Synthesis, Crystal Structure Determination and Its Organic Immobilization on Silica for Efficient Solid-Liquid Extraction of Heavy Metals

“…Research on β-keto-enol derivatives and their metal complexes has been stimulated by their strong complexing properties [8,9]. These types of molecules have two potential coordination sites and can: (i) behave as uni-or bidentate ligand; (ii) coordinate to the metal atom through monoionic or neutral form; and (iii) form a bridge between two metal atoms.…”

In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline

“…Complexation reduces the polarity of metal ion by coordinating with ligands and increases the lipophilicity of the metals. 31 Thus it facilitates the novel synthesized complex to penetrate the lipoid cell membrane of microorganisms and inhibit their growth. No compounds showed any effective antimicrobial activity against C. albicans.…”