Synthesis and in vitro evaluation of palladium(II) salicylaldiminato thiosemicarbazone complexes against Trichomonas vaginalis

Synthesis, characterization and pharmacological evaluation of ferrocenyl azines and their rhodium(I) complexes

“…The corresponding metal complexes 8 e 10, exhibited lower activity compared to their respective un-complexed salicylaldimines suggesting that incorporation of the Rh-COD moiety does not inhibit parasite growth. Compound 5 and 8, the 5-Cl substituted derivatives, exhibited slightly higher parasite growth inhibition compared to the unsubstituted and 3-OMe derivatives which is consistent with literature [57,58]. Ferroquine displayed similar activity to ferrocenyl compounds 5 and 6, while chloroquine exhibited the lowest activity, showing approximately 25% parasite growth inhibition.…”

Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines

“…In recent years, sulfur containing ligands such as dithiocarbamates and thiosemicarbazones and their transition metal complexes have received more attention in the area of medicinal chemistry, due to their pharmacological properties, such as antiviral [1–3], antibacterial [4–7], antifungal [8–10], antiparasitic [11, 12], and antitumor [13–19] activities.…”

Synthesis, structure investigation and biological evaluation of 2-thiophene N(4)-phenylthiosemicarbazone and its three metal derivatives

“…It is reported that the biological activities of thiosemicarbazones are closely related to the parent aldehyde or ketone group, amino-terminal substitution and metal ions [8][9][10][11][12][13]. Moreover, the antitumour activities of thiosemicarbazones increase with their ability coordinating to the metal ions [8][9].…”