Synthesis and in vivo evaluation of novel benzimidazole‐sulfonamide hybrids and Lucilia cuprina maggots' excretion/secretion topical gels for wound healing

Abstract

A novel series of benzimidazole-sulfonamide hybrids (6a-g) was designed, synthesized, and their structures were characterized by 1 H NMR and 13 C NMR spectral data. Further, all compounds were evaluated for their antibacterial effects. The synthesized benzimidazole-sulfonamide hybrid (6d) showed the highest antibacterial activity against Staphylococcus aureus, Staphylococcus epidermis, Escherichia coli, and Klebsiella pneumonia. Different gel formulations for 6d were prepared and physically investigated. After in vivo evaluation for wound healing, the 6d gel formulation delayed the wound healing in animal model. But interestingly, a combination of 6d and Lucilia cuprina maggots' excretion/secretion showed remarkable enhancement in wound healing compared with 6d only. This combination opens up promising prospects for wound healing formulations.

Wound healing and antibacterial activities of water-soluble chitosan nanoparticles and excretion/secretion as a natural combination from medicinal maggots, Lucilia cuprina

“…The ES components such as serine proteases promote the cell migration of fibroblast 45–47 and enhance the tissue formation. 48 Actually, as mentioned in literature, 49 ES enhanced the wound healing activity of novel antibacterial drugs (sulfonamide derivatives). The remarkable advantage of ES was clear after adding ES to the sulfonamide derivatives, where the application of sulfonamide derivatives only delayed the wound healing progress.…”