Background:
Guggulipid, an oleo-gum resin extracted from the bark of Commiphora
wightii of the Burseraceae family, holds a significant place in Ayurvedic medicine due to its historical
use in treating various disorders, including inflammation, gout, rheumatism, obesity, and lipid
metabolism imbalances.
Objective:
This comprehensive review aims to elucidate the molecular targets of guggulipids and
explore their cellular responses. Furthermore, it summarizes the findings from in-vitro, in-vivo,
and clinical investigations related to arthritis and various inflammatory conditions.
Methods:
A comprehensive survey encompassing in-vitro, in-vivo, and clinical studies has been
conducted to explore the therapeutic capacity of guggulipid in the management of rheumatoid
arthritis. Various molecular pathways, such as cyclooxygenase-2 (COX-2), vascular endothelial
growth factor (VEGF), PI3-kinase/AKT, JAK/STAT, nitric oxide synthase (iNOS), and NFκB signaling
pathways, have been targeted to assess the antiarthritic and anti-inflammatory effects of
this compound.
Results:
The research findings reveal that guggulipid demonstrates notable antiarthritic and anti-inflammatory
effects by targeting key molecular pathways involved in inflammatory responses. These
pathways include COX-2, VEGF, PI3-kinase/AKT, JAK/STAT, iNOS, and NFκB signaling
pathways. in-vitro, in-vivo, and clinical studies collectively support the therapeutic potential of
guggulipid in managing rheumatoid arthritis and related inflammatory conditions.
Conclusion:
This review provides a deeper understanding of the therapeutic mechanisms and potential
of guggulipid in the management of rheumatoid arthritis. The collective evidence strongly
supports the promising role of guggulipid as a therapeutic agent, encouraging further research and
development in guggulipid-based treatments for these conditions.
