Synthesis and Insecticidal Activity of Novel N-Oxalyl-N-methylcarbamates

Synthesis of Carbamic Esters Derivatives of Itols: Antifungal Activity against Various Crop Diseases

“…Research has been conducted in our laboratories on new antifungal derivatives from natural products (Len et al, 1996) with the intention to prepare novel propesticides having greater residual effectiveness (Fahmy et al, 1981;Mallipudi et al, 1994) and higher plant systemic activity (Ziegler et al, 1975;Jojima et al, 1983). We have previously described the synthesis of mono(dithiocarbamic esters) such as 1-S-(N,N-diethyldithiocarbamoyl)-1-deoxy-DL-glycerol (17) and bis-(dithiocarbamic esters) of glycerol such as bis[1,3-S-(N,N-diethyldithiocarbamoyl)]-1,3-dideoxyglycerol (21), bis [1,3-S-(morpho-4-yldithiocarbamoyl)]-1,3-dideoxyglycerol ( 22), and bis[1,3-S-(1-piperidyldithiocarbamoyl)]-1, 3-dideoxyglycerol (23) and their in vitro and in vivo activities against different fungi (Len et al, 1996).…”

Synthesis and insecticidal evaluation of novel N-oxalyl derivatives of diacylhydrazines containing methylcarbamate moieties

“…Substituted-phenyl N-methyl(chloroglyoxyloyl)-carbamate 2 was prepared by reaction of oxalyl chloride with substituted-phenyl N-methylcarbamate in 1,2-dichloroethane under reflux according to [11]. N-tert-butyl-N,Ndiacylhydrazine 3 was synthesized according to the reported procedure [15].…”

“…It has been reported that N-oxalyl derivatives of N-methylcarbamates retain the good insecticidal activity of the parent methylcarbamates, and compared to the parent insecticides, the derivatives displayed significantly reduced toxicity to the white mouse at the same time [11]. Encouraged by these reports, we developed an idea that introduction of N-methylcarbamates into N-tert-butyl-N,Ndiacylhydrazines through oxalyl group may retain insecticidal activities of the two parent insecticides, while the toxicity of the parent methylcarbamates to mammals would be reduced at the same time.…”

Design, synthesis, and insecticidal activity of novel neonicotinoid derivatives containing N-oxalyl groups

“…20 It was reported that N-oxalyl derivatives of carbofuran containing a carboxylic acid or ester substituent (8) displayed an insecticidal activity comparable or superior to that of carbofuran. 21 The synthesis and insecticidal evaluation of novel N-oxalyl derivatives of tebufenozide (9) have been reported and the results of bioassay showed that they exhibit excellent larvicidal activity ( Figure 1). …”