Synthesis and Intramolecular Energy- and Electron-Transfer of 3D-Conformeric Tris(fluorenyl-[60]fullerenylfluorene) Derivatives

Abstract

New 3D conformers were synthesized to show a nanomolecular configuration with geometrically branched 2-diphenylaminofluorene (DPAF-C2M) chromophores using a symmetrical 1,3,5-triaminobenzene ring as the center core for the connection of three fused DPAF-C2M moieties. The design led to a class of cis-cup-tris[(DPAF-C2M)-C60(>DPAF-C9)] 3D conformers with three bisadduct-analogous <C60> cages per nanomolecule facing at the same side of the geometrical molecular cis-cup-shape structure. A sequential synthetic route was described to afford this 3D configurated conformer in a high yield with various spectroscopic characterizations. In principle, a nanostructure with a non-coplanar 3D configuration in design should minimize the direct contact or π-stacking of fluorene rings with each other during molecular packing to the formation of fullerosome array. It may also prevent the self-quenching effect of its photoexcited states in solids. Photophysical properties of this cis-cup-conformer were also investigated.

Photoactivation of Chemotherapeutic Agents with Cerenkov Radiation for Chemo-Photodynamic Therapy

“…ABMA-O 2 formation can be monitored spectrophotometrically by decreasing the absorption bands near 378 and 400 nm of ABMA. 6 , 13 , 15 , 30 When ABMA-O 2 is formed, the absorption of ABMA decreases proportionally to the amount of 1 O 2 generated by the type II photodynamic reaction. 6 , 13 , 30 The decrease in ABMA absorption once 1 O 2 was produced is irreversible.…”

“… 6 , 13 , 15 , 30 When ABMA-O 2 is formed, the absorption of ABMA decreases proportionally to the amount of 1 O 2 generated by the type II photodynamic reaction. 6 , 13 , 30 The decrease in ABMA absorption once 1 O 2 was produced is irreversible. Therefore, this method is convenient when CR is used as light source because it allows the measurement of ABMA absorbance after 18 F-FDG total decay, avoiding the handle of the radioactive sample.…”

“…To estimate the presence of 1 O 2 by UV–vis spectrophotometry, ABMA was used, an anthracene derivative that reacts selectively with 1 O 2 , forming a non-fluorescent 9,10-endoperoxide (ABMA-O 2 ). ABMA-O 2 formation can be monitored spectrophotometrically by decreasing the absorption bands near 378 and 400 nm of ABMA. ,,, When ABMA-O 2 is formed, the absorption of ABMA decreases proportionally to the amount of 1 O 2 generated by the type II photodynamic reaction. ,, The decrease in ABMA absorption once 1 O 2 was produced is irreversible. Therefore, this method is convenient when CR is used as light source because it allows the measurement of ABMA absorbance after 18 F-FDG total decay, avoiding the handle of the radioactive sample.…”

“…This result indicates that the decrease in ABMA absorbance upon the addition of 250 μCi (9.25 MBq) of 18 F-FDG is unlikely to be a product of radiolysis since the signal was not affected by activities of 500 (18.5 MBq) and 750 μCi (27.75 MBq) of 18 F-FDG. We hypothesize that CR from 18 F-FDG is more likely to cause ABMA excitation to a state (probably triplet, according to Yin et al 31 ) in which it absorbs fewer photons without breaking down. As the amount of ABMA in the solutions is constant, increasing the intensity of the CR of 18 F-FDG does not increase the amount of excited ABMA, so the absorbance remains almost constant.…”

Supramolecular and base-induced singlet oxygen generation enhancement of a water-soluble phthalocyanine

“…The SO-generating ability of the gels was assessed using ABMA, a fluorescent probe which reacts with singlet oxygen producing a non-fluorescent (in visible spectrum) endoperoxide compound and reducing the overall ABMA fluorescence emision between ~ 400 -500 nm [35]. A diode laser of 660 nm was used to excite the Q-band of ZnPcTS, and subsequently generate SO.…”