Synthesis and investigation of a tris-cyclometalated iridium complex bearing a single quarternary ammonium group

Meksawangwong, Sureemas; Gohil, Bhavini; Punyain, Wikorn; Pál, Róbert; Kielar, Filip

doi:10.1016/j.ica.2019.119066

Cited by 7 publications

(4 citation statements)

References 25 publications

(38 reference statements)

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“…We have recently published a report on a quarternary ammonium salt of the butyl substituted complex, in addition to the previously mentioned report on the complexes bearing the butyl and dodecyl chain. [21][22] Our previously reported complexes have displayed lysosomal localization. However, the quarternary ammonium complex stood out in terms of its significantly lower cytotoxicity.…”

Section: Cellular Experimentsmentioning

confidence: 92%

“…The first one was synthesized as a direct analogue of the previously reported complexes containing simple alkyl groups while the latter was synthesized with reduced cytotoxicities in mind as it was observed for complexes where the secondary amino group is transformed into its tertiary amino analogue or a quarternary ammonium group. [21][22] Figure 1. Structures of tris-cyclometalted aminoalkyl iridium complexes reported by our group.…”

Section: Introductionmentioning

confidence: 99%

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Development of tris-cyclometalated iridium complexes for cellular imaging through structural modification

Meksawangwong

Gohil

Punyain

et al. 2020

Inorganica Chimica Acta

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Section: Cellular Experimentsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Development of tris-cyclometalated iridium complexes for cellular imaging through structural modification

Meksawangwong

Gohil

Punyain

et al. 2020

Inorganica Chimica Acta

Self Cite

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“…Additionally, the light-responsive rotaxane exhibits substantially increased cytotoxic activity upon continuous irradiation, resulting from the translocation of the platinum(II) salphen complex to the cell nucleus and its binding to DNA. Vaźquez, Vilar, and coworkers have developed dimeric platinum(II) salophen complexes linked with different peptide sequences (507) for targeting multimeric G-quadruplex DNA. 944 The peptide linker plays an important role in the binding affinity and selectivity of the complexes toward different G-quadruplex DNA topologies.…”

Section: Nucleic Acidsmentioning

confidence: 99%

“…Furthermore, a water-soluble iridium(III) complex carrying two morpholine units ( 275 ) has been developed for lysosome-targeted imaging and PDT . Kielar and co-workers have demonstrated that iridium(III) complexes containing a pH-sensitive aminoalkyl moiety ( 276 and 277 ) can also specifically target the lysosomes. − …”

Section: Luminescent Transition Metal Complexes As Probes For Specifi...mentioning

confidence: 99%

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Lee,

2024

Chem. Rev.

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Luminescence imaging is a powerful and versatile technique for investigating cell physiology and pathology in living systems, making significant contributions to life science research and clinical diagnosis. In recent years, luminescent transition metal complexes have gained significant attention for diagnostic and therapeutic applications due to their unique photophysical and photochemical properties. In this Review, we provide a comprehensive overview of the recent development of luminescent transition metal complexes for bioimaging and biosensing applications, with a focus on transition metal centers with a d 6 , d 8 , and d 10 electronic configuration. We elucidate the structure−property relationships of luminescent transition metal complexes, exploring how their structural characteristics can be manipulated to control their biological behavior such as cellular uptake, localization, biocompatibility, pharmacokinetics, and biodistribution. Furthermore, we introduce the various design strategies that leverage the interesting photophysical properties of luminescent transition metal complexes for a wide variety of biological applications, including autofluorescence-free imaging, multimodal imaging, organelle imaging, biological sensing, microenvironment monitoring, bioorthogonal labeling, bacterial imaging, and cell viability assessment. Finally, we provide insights into the challenges and perspectives of luminescent transition metal complexes for bioimaging and biosensing applications, as well as their use in disease diagnosis and treatment evaluation.

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Studies of anticancer activity in vivo and in vitro behaviors of liposomes encapsulated iridium(III) complex

Wen

Zhang

et al. 2021

J Biol Inorg Chem

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Synthesis and investigation of a tris-cyclometalated iridium complex bearing a single quarternary ammonium group

Abstract: Synthesis and investigation of a tris-cyclometalated iridium complex bearing a single quarternary ammonium group.', Inorganica chimica acta., 497. p. 119066.

Cited by 7 publications

References 25 publications

Development of tris-cyclometalated iridium complexes for cellular imaging through structural modification

Development of tris-cyclometalated iridium complexes for cellular imaging through structural modification

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Studies of anticancer activity in vivo and in vitro behaviors of liposomes encapsulated iridium(III) complex

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