Synthesis and magneto-structural properties of chitosan coated ultrafine cobalt ferrite nanoparticles for magnetic fluid hyperthermia in viscous medium

Anila, I.; Lahiri, B.B.; M, Jacob Mathew; Philip, John

doi:10.1016/j.ceramint.2022.04.088

Cited by 11 publications

(5 citation statements)

References 84 publications

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“…The bare Fe 3 S 4 MNPs exhibited a zeta potential of ∼ −12.9 ± 1.2 mV (figure 6(c)), which was not sufficient to provide adequate electrostatic stabilization in the aqueous medium. These observations were in agreement with the experimental findings earlier reported for uncoated cobalt ferrite MNPs [34] and nano-aggregates [102]. Earlier studies by Pilati et al [103], and Obaidat et al [104], reported the importance of colloidal stability of the MNP dispersions for superior AMF induced heating efficiency.…”

supporting

confidence: 92%

“…Several studies have probed the variations of SAR with the magneto-structural properties of the MNPs with an objective to optimize the heating efficiency [29,30]. Though superparamagnetic iron oxide MNPs (magnetite or maghemite) are the most widely studied systems for magnetic hyperthermia [31,32], other types of ferrites [33][34][35] and Fe-carbides, -nitrides and -borides [36] have also been used. Apart from the synthetic MNPs, bacterial magnetosomes have exhibited large AMF induced heating efficiency [37,38].…”

Section: Introductionmentioning

confidence: 99%

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Physicochemical properties and AC magnetic field induced heating properties of solvothermally prepared thiospinel: Fe₃S₄ (greigite) nanoparticles

et al. 2023

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The presence of greigite (Fe3S4) nanoparticles in bacterial magnetosomes, and its lower toxicity have emerged as favourable aspects for its potential applications in various bio-medical applications, including magnetic hyperthermia. Despite having a number of intriguing features, systematic research on the heating efficiency of Fe3S4 nanoparticles (MNPs) in an AC magnetic field is scarce, which is primarily due to the difficulties in preparing phase pure greigite MNPs. In this study, greigite MNPs are prepared using a solvothermal approach, utilizing ethylene glycol as a solvent, and surface functionalized with varied concentrations of poly vinyl alcohol (PVA). Studies using powder X-ray diffraction and electron microscopy demonstrate the development of crystalline Fe3S4 MNPs (average crystallite size: 19–23 nm) with flaky or flower-like morphology. X-ray photoelectron spectroscopy indicates that the lattice is composed primarily of iron and sulphur. The existence of bio-compatible PVA polymer on the surface of the coated MNPs is confirmed using Fourier transform infrared spectroscopy. For the uncoated MNPs, the magnetization at 90 kOe and the effective anisotropy energy density values are found to be ~ 5.2 emu/g and ~ 22.3 kJ/m3, respectively. Due to improved colloidal stability, magneto-calorimetric experiments reveal higher AC magnetic field induced heating efficiency for PVA-coated MNPs. The highest specific absorption rate (SAR) is obtained as ~ 67.8 ± 2.6 W/gFe in the current study, which is several times higher than the previously published values for synthetic Fe3S4 MNPs. Furthermore, for samples with comparable saturation magnetization and crystallite size, SAR is found to increase with initial susceptibility. The in vitro cytotoxicity studies show good bio-compatibility for the prepared greigite MNPs. The experimental findings provide deeper insights into the preparation of Fe3S4 MNPs using a simple solvothermal technique, and its AC magnetic field induced heating efficiency.

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confidence: 92%

Section: Introductionmentioning

confidence: 99%

Physicochemical properties and AC magnetic field induced heating properties of solvothermally prepared thiospinel: Fe₃S₄ (greigite) nanoparticles

et al. 2023

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“…Amongst the bio-compatible organic moieties used for surface stabilization of MNPs, chitosan is one of the most widely used bio-polymeric candidates. Chitosan demonstrates several interesting bio-medical properties such as bio-adhesiveness, film-forming ability, wound-healing ability, low toxicity, and bio-degradability (lysozyme-mediated metabolism) [4,6]. Chemically, chitosan is an amino-polysaccharide consisting of β-(1-4)-linked N-acetyl-2-amino-2-deoxy-Dglucose and 2-amino-2-deoxy-D-glucose [7], where the presence of the two primary amine groups imparts strong pHdependent colloidal properties [4,8].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, deprotonation of the amine groups at higher pH makes chitosan increasingly insoluble in aqueous dispersions, giving rise to significant colloidal destabilization [8]. Chitosancoated MNPs have been used in a variety of biomedical applications, like magnetic resonance imaging [9,10], DNA separation [11], drug delivery [12,13], and MFH [6,[14][15][16]. In MFH, when the MNPs are exposed to an alternating magnetic field (AMF), the heating is due to the Neel-Brown relaxation losses [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

A nudge over the relaxation plateau: effect of pH, particle concentration, and medium viscosity on the AC induction heating efficiency of biocompatible chitosan-coated Fe₃O₄ nanoparticles

Mahendravada,

Lahiri,

Khan

et al. 2024

Nanotechnology

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The effect of pH, MNP concentration, and medium viscosity on the magnetic fluid hyperthermia (MFH) properties of chitosan-coated superparamagnetic Fe3O4 nanoparticles (MNPs) are probed here. Due to the protonation of the amide groups, the MNPs are colloidally stable at lower pH (~2), but form aggregates at higher pH (~ 8). The increased aggregate size at higher pH causes the Brownian relaxation time (τB) to increase, leading to a decrease in specific absorption rate (SAR). For colloidal conditions ensuring Brownian-dominated relaxation dynamics, an increase in MNP concentrations or medium viscosity is found to increase the τB. SAR decreases with increasing MNP concentration, whereas it exhibits a non-monotonic variation with increasing medium viscosity. Dynamic hysteresis loop-based calculations are found to be in agreement with the experimental results. The findings provide a greater understanding of the variation of SAR with the colloidal properties and show the importance of relaxation dynamics on MFH efficiency, where variations in the frequency-relaxation time product across the relaxation plateau cause significant variations in SAR. Further, the in vitro cytotoxicity studies show good bio-compatibility of the chitosan-coated Fe3O4 MNPs. Higher SAR at acidic pH for bio-medically acceptable field parameters makes the bio-compatible chitosan-coated Fe3O4 MNPs suitable for MFH applications.

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“…In previous research, chitosan-coated superparamagnetic iron oxide nanoparticles and ferrites were examined for applications in drug delivery and hyperthermia [33]. However, there has been limited exploration into the potential of cobalt-zinc ferrite in this context.…”

Section: Introductionmentioning

confidence: 99%

Chitosan decorated cobalt zinc ferrite nanoferrofluid composites for potential cancer hyperthermia therapy: anti-cancer activity, genotoxicity, and immunotoxicity evaluation

Sharifi,

Reisi,

Yousefiasl

et al. 2023

Adv Compos Hybrid Mater

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Cancer, as the leading cause of death worldwide, has been constantly increasing in mortality every year. Among several therapeutics, nanoscale compounds showed promising results in overcoming cancer diseases. There are numerous types of research on the paramagnetic nanoparticles of iron oxide, which cause apoptosis and cancer cell death. In this study, cobalt/zinc/ferrite nanoferrofluid composites (~ 39 nm) were synthesized and decorated with chitosan to enhance the cell entry for potential applications in cancer therapy. The neat and chitosan-adorned cobalt zinc ferrite nanoferrofluid composites (~ 94 nm) displayed superparamagnetic properties. The nanocomposite exhibited anti-cancer activity against WEHI164 cancer cells in a dose- and time-dependent manner. The chitosan-coated nanocomposite was found to induce oxidative stress in WEHI164 cancer cells, as indicated by reactive oxygen species (ROS) production. Furthermore, DNA damage was indicated in WEHI164 cancer cells after exposure to chitosan-coated nanocomposites. Chitosan-coated nanocomposites promoted dendritic cell maturation by inducing the release of interleukin-6 proinflammatory cytokines. According to the results and ancillary studies, superparamagnetic nanoparticles coated with chitosan can be considered an effective and promising treatment for the destruction of cancer cells. Graphical Abstract Summary: Chitosan decorated cobalt zinc ferrite nanoferrofluid composites was fabricated for potential cancer hyperthermia therapy with high biocompatibility.

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Synthesis and magneto-structural properties of chitosan coated ultrafine cobalt ferrite nanoparticles for magnetic fluid hyperthermia in viscous medium

Cited by 11 publications

References 84 publications

Physicochemical properties and AC magnetic field induced heating properties of solvothermally prepared thiospinel: Fe₃S₄ (greigite) nanoparticles

Physicochemical properties and AC magnetic field induced heating properties of solvothermally prepared thiospinel: Fe₃S₄ (greigite) nanoparticles

A nudge over the relaxation plateau: effect of pH, particle concentration, and medium viscosity on the AC induction heating efficiency of biocompatible chitosan-coated Fe₃O₄ nanoparticles

Chitosan decorated cobalt zinc ferrite nanoferrofluid composites for potential cancer hyperthermia therapy: anti-cancer activity, genotoxicity, and immunotoxicity evaluation

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Synthesis and magneto-structural properties of chitosan coated ultrafine cobalt ferrite nanoparticles for magnetic fluid hyperthermia in viscous medium

Cited by 11 publications

References 84 publications

Physicochemical properties and AC magnetic field induced heating properties of solvothermally prepared thiospinel: Fe3S4 (greigite) nanoparticles

Physicochemical properties and AC magnetic field induced heating properties of solvothermally prepared thiospinel: Fe3S4 (greigite) nanoparticles

A nudge over the relaxation plateau: effect of pH, particle concentration, and medium viscosity on the AC induction heating efficiency of biocompatible chitosan-coated Fe3O4 nanoparticles

Chitosan decorated cobalt zinc ferrite nanoferrofluid composites for potential cancer hyperthermia therapy: anti-cancer activity, genotoxicity, and immunotoxicity evaluation

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Product

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Physicochemical properties and AC magnetic field induced heating properties of solvothermally prepared thiospinel: Fe₃S₄ (greigite) nanoparticles

Physicochemical properties and AC magnetic field induced heating properties of solvothermally prepared thiospinel: Fe₃S₄ (greigite) nanoparticles

A nudge over the relaxation plateau: effect of pH, particle concentration, and medium viscosity on the AC induction heating efficiency of biocompatible chitosan-coated Fe₃O₄ nanoparticles