Synthesis and Medicinal Applications of Benzimidazoles: An Overview

Rajasekhar, Sreerama; Maiti, B. R.; Balamurali, M. M.; Chanda, Kaushik

doi:10.2174/1570179413666160818151932

Cited by 53 publications

(36 citation statements)

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“…Various strategies have been introduced for the synthesis of N,N’ ‐diarylformamidines, benzoxazoles, benzothiazoles and benzimidazoles under the influence of different catalysts . Learning from those achievements, at this time and for the first time, we tried to create a new highly powerful heterogeneous nano catalyst by the use of a PMO system containing N ‐SO 3 H groups located in the pore walls.…”

Section: Resultsmentioning

confidence: 99%

Periodic Mesoporous Organosilica Containing Bridged N‐Sulfonic Acid Groups: Promotion of the Synthesis of N,N’‐Diarylformamidines, Benzoxazoles, Benzothiazoles and Benzimidazoles

2019

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In this study, the successful synthesis of periodic mesoporous organosilica containing bridged N‐sulfonic acid groups (SA‐PMO) is demonstrated. The formation and morphology of the reagent were confirmed by N2 adsorption‐desorption isotherms and pH measurement, X‐ray diffraction (XRD), transmission electron microscopy (TEM) and Fourier transform infrared (FT‐IR) analysis. After identification, the catalytic activity of this reagent was investigated in the synthesis of N,N’‐diarylformamidines, benzoxazoles, benzothiazoles and benzimidazoles. Eco‐friendly protocol, excellent yields, short reaction times, ease of preparation, reusability of the catalyst and easy isolation of the products are the main advantages of this protocol. The considerable efficiency of the catalyst can be related to its high surface area, large pore volume and high acidity.

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Section: Resultsmentioning

confidence: 99%

Periodic Mesoporous Organosilica Containing Bridged N‐Sulfonic Acid Groups: Promotion of the Synthesis of N,N’‐Diarylformamidines, Benzoxazoles, Benzothiazoles and Benzimidazoles

2019

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“…Nitrogen‐containing heterocyclic precursors are useful structural motifs found in natural as well as in synthetic compounds. Among them, benzimidazoles hold important role due to their omnipresence in natural products, pharmaceuticals and in biologically active compounds . These compounds consist various biological activities such as bactericides, anti‐carcinogens, and peptic ulcer activities .…”

Section: Methodsmentioning

confidence: 99%

Supported Rhodium (Rh@PS) Catalyzed Benzimidazoles Synthesis Using Ethanol/Methanol as C₂H₃/CH Source

Sharma

Yamini

et al. 2018

Adv Synth Catal

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An effective and stable polystyrene supported rhodium (Rh@PS) nano-catalyst has been synthesized by following reduction-deposition approach and applied for the selective benzimidazoles synthesis from 1,2-phenylenediamines and ethanol/ methanol as C 2 H 3 /CH source. The ethanol/methanol in the presence of trace amounts of aerobic oxygen under Rh@PS catalysed condition, first participated in oxidation of alcohol followed by consecutive condensation, cyclization and hydrogen elimination reactions with 1,2-phenylenediamine gave the desired products in good yields. The Rh@PS catalyst in a single system performed both oxidation and reduction reactions in a selective/ specific manner and applied for large substrate scope. Easy recovery, handling, stability, recyclability of the catalyst and less chance of metal contamination with the products are the added advantages of the process.

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“…Nitrogen heterocycles are the most profuse in nature specifically those having oxygen, sulfur owing to their extensive disposition in nucleic acid exemplification and contribution in nearly each physiological process of organisms . Benzimidazoles have practical applications in medicinal chemistry ascribed to its diverse biological functions such as antibacterial, anticancer, antiviral, fungicidal, analgesic properties. Benzimidazoles are also possess antitumor activity as being a DNA binding agent.…”

Section: Introductionmentioning

confidence: 99%

Sulfated Tin Oxide: An Immensely Potent and Reusable Catalyst for the Synthesis of Benzimidazole Derivatives

Kagne

Niwadange

Kalalawe

et al. 2019

Macromolecular Symposia

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In this research, a new strategy for synthesis of benzimidazoles via condensing o‐phenylenediamine and substituted aldehydes by adopting prepared sulfated tin oxide as solid heterogenous catalyst in water ethanol system (1:1‐v/v) at reflux condition has been developed. The solid sulfated tin oxide is synthesized and confirmed by XRD, EDS map, SEM images, and FTIR. The reaction is optimized for different solvents and loading of catalyst. The yields of all benzimidazole derivatives are observed in the range of 80–94%. All the synthesized benzimidazoles are analyzed by spectral data. The use of ecologically benign catalyst sulfated tin oxide, solvent system, ample substrate scope with good atom economy, environmental affordability, and easy work up makes this protocol green.

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Synthesis and Medicinal Applications of Benzimidazoles: An Overview

Cited by 53 publications

References 0 publications

Periodic Mesoporous Organosilica Containing Bridged N‐Sulfonic Acid Groups: Promotion of the Synthesis of N,N’‐Diarylformamidines, Benzoxazoles, Benzothiazoles and Benzimidazoles

Periodic Mesoporous Organosilica Containing Bridged N‐Sulfonic Acid Groups: Promotion of the Synthesis of N,N’‐Diarylformamidines, Benzoxazoles, Benzothiazoles and Benzimidazoles

Supported Rhodium (Rh@PS) Catalyzed Benzimidazoles Synthesis Using Ethanol/Methanol as C₂H₃/CH Source

Sulfated Tin Oxide: An Immensely Potent and Reusable Catalyst for the Synthesis of Benzimidazole Derivatives

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Synthesis and Medicinal Applications of Benzimidazoles: An Overview

Cited by 53 publications

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Periodic Mesoporous Organosilica Containing Bridged N‐Sulfonic Acid Groups: Promotion of the Synthesis of N,N’‐Diarylformamidines, Benzoxazoles, Benzothiazoles and Benzimidazoles

Periodic Mesoporous Organosilica Containing Bridged N‐Sulfonic Acid Groups: Promotion of the Synthesis of N,N’‐Diarylformamidines, Benzoxazoles, Benzothiazoles and Benzimidazoles

Supported Rhodium (Rh@PS) Catalyzed Benzimidazoles Synthesis Using Ethanol/Methanol as C2H3/CH Source

Sulfated Tin Oxide: An Immensely Potent and Reusable Catalyst for the Synthesis of Benzimidazole Derivatives

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Supported Rhodium (Rh@PS) Catalyzed Benzimidazoles Synthesis Using Ethanol/Methanol as C₂H₃/CH Source