Synthesis and micellization of an amphiphilic biodegradable β-cyclodextrin/poly(γ-benzyl L-glutamate) copolymer

Wu, Qiu Hua; Fang, Liang; Wei, Tian Zhu; Song, Xingguo; Liu, Da Liang; Zhang, Guo Lin

doi:10.1007/s10965-009-9304-9

Cited by 8 publications

(2 citation statements)

References 27 publications

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“…New aliphatic polycarbonates based on DL-lactide, carbon dioxide (CO 2 ), and propylene oxide have also shown improvements over poly(lactic acid) and poly(glycolic acid) in medical applications [31]. Other recently reported starting materials for degradable polymers include caffeic acid and p-hydroxybenzoic acid [32] and cyclodextrin and glutamic acid derivatives [33]. A unique application of degradable plastics has been conversion of microbially produced poly(hydroxyalkanoates) (PHAs) into ester fragments that can be blended with gasoline.…”

Section: Biodegradable Plasticsmentioning

confidence: 99%

Green chemistry in China

Cui

Beach

Anastas

2011

Pure and Applied Chemistry

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The principles of green chemistry provide a framework for rational design of environmentally friendly chemicals and chemical processes having reduced intrinsic hazard. In China, the academic community has made advances in key areas, developing new catalysts, solvents, polymers, plastics additives, and biomass transformations that add to the "toolbox" of alternative, more benign, and transformative technologies. Educational and outreach activities have also flourished in recent years. This perspective highlights examples of green chemistry breakthroughs in China, focusing on literature reports from 2008 to 2010. While we cannot hope to be comprehensive, we aim to provide examples that demonstrate the scope of the current research field.

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Section: Biodegradable Plasticsmentioning

confidence: 99%

Green chemistry in China

Cui

Beach

Anastas

2011

Pure and Applied Chemistry

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“…The sizes of amphiphilic copolymeric nanoparticles affect molecular weight and intermolecular interactions. 37,38 The particle size of the FA-PEG-PBLA copolymeric nanoparticles ranged from 105 to 124 nm (Table 1). Nanoparticle size gradually increased as the molecular weight of FA-PEG-PBLA and the hydrophobic PBLA segment increased.…”

Section: Resultsmentioning

confidence: 99%

Self-assembled photosensitizer-conjugated nanoparticles for targeted photodynamic therapy

et al. 2012

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An effective tumor-targeted drug delivery system for photodynamic therapy was developed by designing ligand-mediated nanoparticles with stable formulations of a hydrophobic photosensitizer. Novel folic acid (FA)-conjugated amphiphilic block copolymers of polyethylene glycol (PEG) and poly-β-benzyl-L-aspartate (PBLA) with the potential to act as pH-responsive drug release reservoirs were synthesized. The photosensitizer, 2,4-diacetyl deuteroporphyrin IX dimethyl ether (DD-PpIX), was conjugated to the copolymers through pH-sensitive hydrazone linkage. The syntheses and compositions of all copolymers were confirmed by ¹H NMR measurement. Photosensitizer-conjugated amphiphilic copolymeric nanoparticles (FA-PEG-P(Asp-Hyd)-DD-PpIX) were prepared by micelle formation in aqueous solution. The particle sizes of the FA-PEG-PBLA and FA-PEG-P(Asp-Hyd)-DD-PpIX nanoparticles were determined by light-scattering measurements. The range was 105-298 nm, depending on copolymer molecular weight and composition. Field emission scanning electron microscopy showed that the FA-PEG-P(Asp-Hyd)-DD-PpIX copolymeric nanoparticles were submicron in size and spherical in shape. The results of in vitro release tests showed that the release profiles of DD-PpIX from the nanoparticles were strongly pH-dependent and influenced by the amount of photosensitizer that was conjugated. In vitro tests using HeLa cells indicated that the FA-PEG-P(Asp-Hyd)-DD-PpIX nanoparticles had low dark-toxicity and showed more than 97% of cellular uptake. Based on our results, the FA-PEG-P(Asp-Hyd)-DD-PpIX nanoparticle system could be a promising approach for developing novel photosensitizer delivery carriers for photodynamic therapy.

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