Synthesis and microstructural properties of the scaffold based on a 3-(trimethoxysilyl)propyl methacrylate–POSS hybrid towards potential tissue engineering applications

John, Łukasz; Janeta, Mateusz; Rajczakowska, Magdalena; Ejfler, Jolanta; Łydżba, Dariusz; Szafert, Sławomir

doi:10.1039/c6ra10364b

Cited by 35 publications

(15 citation statements)

References 48 publications

(54 reference statements)

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“…47,48 To date, our recent studies, reported in 5, have indicated that hexahedral organic-inorganic hybrids based on a siloxane cage-like core with eight 3-(trimethoxysilyl)propyl methacrylate side arms can be considered unique three-dimensional scaffolds that fulfil potential hard-tissue-engineering requirements realized by multiple factors such as the chemical composition, structural dimensions, topography, and microstructural properties. 34 Our investigations also prove that the methacrylate derivatives used, not only those attached to the Si 8 O 12 cage, are safe components and constitute efficient reservoirs for osteoblasts. 42 For this reason, they may be used in future experiments, as they do not have any toxic influence on cells.…”

Section: Poss-based Biomaterials Containing Methacrylatederived Sidesupporting

confidence: 58%

“…[31][32][33] Recently, we have reported on the synthesis of biohybrids based on the 3-(trimethoxysilyl)propyl methacrylate-POSS compound. 34 Inspired by those studies, spherosilicate 2 was functionalized in this work by (2-hydroxyethyl)methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) monomers giving [OAS-POSS-NH]HEMA (3) and [OAS-POSS-NH]EGDMA (4), respectively. These organic monomers were used because they constitute commonly applied agents in medical biomaterials.…”

Section: Synthesis and Characterization Of Fully Functionalized Methamentioning

confidence: 99%

“…3). 34 These species seem to be promising from the potential hard-tissueengineering point of view. In vitro studies carried out on POSSs constitute strong evidence for their low cytotoxicity.…”

Section: Poss-based Biomaterials Containing Methacrylatederived Sidementioning

confidence: 99%

“…4). 34,[41][42][43] Silicon-based systems can create a perfect environment for biomineralization leading to the formation of bone-like apatites and other calcium phosphates. We showed that methacrylate-derived materials after exposition in biological fluids (Dulbecco's Modified Eagle's Medium) force the crystallization of hydroxyapatite on their surface after merely 0.5 h of incubation.…”

Section: A Brief Comment On the Biological Assessment Of Methacrylatementioning

confidence: 99%

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Synthesis of cubic spherosilicates for self-assembled organic–inorganic biohybrids based on functionalized methacrylates

2018

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Section: Poss-based Biomaterials Containing Methacrylatederived Sidesupporting

confidence: 58%

Section: Synthesis and Characterization Of Fully Functionalized Methamentioning

confidence: 99%

Section: Poss-based Biomaterials Containing Methacrylatederived Sidementioning

confidence: 99%

Section: A Brief Comment On the Biological Assessment Of Methacrylatementioning

confidence: 99%

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Synthesis of cubic spherosilicates for self-assembled organic–inorganic biohybrids based on functionalized methacrylates

2018

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“…Micro-CT can be used to investigate completely (over the entire adhesive volume) and accurately the width of the dental adhesive layer, as also demonstrated in this work. It can detect microleakage areas generated by gaps between the tooth interface and the composite filling material, as approached in numerous studies [69][70][71]. Nowadays, a requirement of dental research is to analyze samples in a non-destructive manner.…”

Section: Comparison Between Optical Microscopy and Micro-ct Resultsmentioning

confidence: 99%

Dental Adhesive Interfaces Reinforced with Magnetic Nanoparticles: Evaluation and Modeling with Micro-CT versus Optical Microscopy

et al. 2020

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Dental adhesives are used in a wide range of applications, including to place direct composite restorations in frontal or posterior teeth. One of the most frequent causes for the failure of composite resin restorations is microleakages. The first aim of this work is to introduce a new type of self-etched dental adhesive doped with magnetic nanoparticles (MPs) synthetized in the laboratory. The scope is to produce adhesives with a minimized width/thickness to decrease the risk of microleakages. The second aim is to assess the width/thickness of the adhesive layer in all the characteristic areas of the teeth using both the less precise but most common optical microscopy and the more accurate and volumetric micro-Computed Tomography (CT) investigations. Twenty extracted teeth have been divided into four groups: Group 1 includes ‘blank’ samples with adhesives that are not doped with MPs; Group 2 includes samples with adhesives doped with MPs; Groups 3 and 4 include samples with adhesives doped with MPs that are subjected to an active magnetic field for 5 and 10 min, respectively. Microscopy investigations followed by micro-CT and EDAX are performed on the adhesive. While a rather good agreement is obtained between the microscopy and micro-CT results, the capability of the latter to offer a full volumetric reconstruction of the layer is exploited to analyze the adhesion of the four considered dental materials. Thus, from micro-CT results the graphs of the surface areas as functions of the adhesive layer width are modeled mathematically, as well as the volume of sealants, for each of the four groups. To our knowledge, it is the first time that such a methodology is used. Characteristic parameters are extracted and the ascertainment of the optimal parameter that should be utilized for such assessments is discussed. The study demonstrates the adhesion improvement produced for Groups 3 and 4, where MPs are used. It also concludes that the magnetic field should be applied to the adhesive material for the longest possible exposure time (with a trade-off with the clinical duration of the treatment).

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Polymerization Induced by Light

Lalevée

Fouassier

2022

Macromolecular Engineering

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The present article presents an overview of photopolymerization reactions and is focused on photoinitiators, photosensitizers, radical and cationic monomers and oligomers, the film photopolymerization of acrylates, epoxides, vinyl ethers, thiol–enes, waterborne light‐curable systems, UV powder formulations, charge‐transfer monomers, dual cure and hybrid cure systems, the general functional properties of the cured materials, the applications, etc. The kinetics, the monitoring of the photopolymerization, the investigation of the excited state processes, the access to the rate constants of the chemical reactions, the solution and bulk reactivity, and the photochemical and chemical reactivity are also discussed.

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Synthesis and microstructural properties of the scaffold based on a 3-(trimethoxysilyl)propyl methacrylate–POSS hybrid towards potential tissue engineering applications

Abstract: The biomimetic organic–inorganic scaffold with the chemical composition, structural dimensions, topography, and microstructural properties that fulfills the requirements for hard-tissue engineering was developed.

Cited by 35 publications

References 48 publications

Synthesis of cubic spherosilicates for self-assembled organic–inorganic biohybrids based on functionalized methacrylates

Synthesis of cubic spherosilicates for self-assembled organic–inorganic biohybrids based on functionalized methacrylates

Dental Adhesive Interfaces Reinforced with Magnetic Nanoparticles: Evaluation and Modeling with Micro-CT versus Optical Microscopy

Polymerization Induced by Light

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