Synthesis and molecular properties of formic hydrazides

Synthesis, spectroscopic characterization of new heterocycles based on sulfamethoxazole as potent antimicrobial agents

“…).The excess of remaining solvent was evaporated and thenthe formed solid was filtered off, recrystallized from acetone to give the final product. [17]…”

“…The reaction mixture then reflexed about (8-10 hrs.). The separated solid was filtered, dried and recrystallized from mixed solvents ethanolwater (1:1) for compound (14)dioxane for compounds (15,17) and chloroform forcompound ( 16) respectively to yield favorites oxazepine products. [19] 2.11.…”

“…Antimicrobial study. In order to measure antibacterial activity of newly prepared compounds (3)(4)(5)(6)(7)(8), (14)(15)(16)(17), a plate of two type of Gram positive bacterial strains [Enterococcus faecalis (EF),Staphylococcus aureus (SA)] and two type of Gram negative bacterial strains [Pseudomonas aeruginosa (PA), Klebsiella pneumonia (KP)]. The antifungal activity was assayed against two type of pathogenic yeast like fungi [Aspergillus niger (AN), Candida albicans (CA)].The activities were evaluatedin vitro using the agar disc diffusion method.…”

“…v(NO2)and (3215 cm -1 ) for v(O-H) respectively. All details of FT-IR spectral data forimine derivatives (10-13) are listed in Table - (17) gives the important characteristic signals related to three protons of methyl group attached to isoxazole ring, two protons of methylene group (NH-CH2-CO), one proton for (CH) group of oxazepine ring, one proton of (CH) isoxazole ring, thirteen aromatic ring protons, three protons of secondary amine (NH) in different positions, one proton for hydoxylgroup (-OH) and one proton of amine group attached to SO2respectively as shown in Table -3. On the other hand characteristic signals for 13 C-NMR spectrum of oxazepine compound (17) showed results in a similar manner to compound (14) are listed in Table-4.…”

“…The inhibition zone of the newly synthesized sulfamethoxazole derivatives (3)(4)(5)(6)(7)(8) and (14)(15)(16)(17) were observed and measured. The antibacterial activities of these compounds were performed against some types of pathogenic bacterial isolates while antifungal activities are evaluated against some yeast similar to fungi.The obtained results of these study are summarized in Table - The results showed that several of the synthesized sulfamethoxazole derivatives displayed notable antimicrobial activity.…”