Synthesis and Neurotropic Activity of Novel Quinoline Derivatives

Abstract

Hydroxyalkyl and carboxyalkyl derivatives of silatetrahydroisoquinoline, tetrahydroisoquinoline and tetrahydroquinoline have been synthesized. Their neurotropic activity has been investigated.

Synthesis, Structure, and Fluxionality of Strained Hypercoordinate Silicon‐Bridged [1]Ferrocenophanes

“…The geometry about nitrogen approaches tetrahedral with C-N-C angles ranging from 106.8(7) to 113.3(7)8 and averaging 109.58. Although the synthesis of several compounds that incorporate the cationic SiCNC 3 ring structure have been previously reported, [26] none of these reports include characterization by X-ray crystallography.…”

Synthesis and characterization of nanoparticles with an iron oxide magnetic core and a biologically active trialkylsilylated aliphatic alkanolamine shell

“…To overcome the problem of colloid system stability the parent alkanolamine has been modified by introduction of organosilicon substituent and by preparing of salt of silyl modified substance. Introduction of organosilicon substituent into the molecule of alkanolamine is an attractive and original approach to the lipophilicity increase [12][13][14][15] interaction with lipophilic chains of the first coating. The transformation of the compounds into salts in many cases causes activity increase, but also changes (increases) the solubility of the compounds in water, that is very significant for preparing and stabilization of water bilayer colloid systems, used for biological purposes.…”

Solvent-free Synthesis of 1,2-Disubstituted Derivatives of 1,2- Dihydroisoquinoline, 1,2-Dihydroquinoline and 1,2-Dihydropyridine

“…In particular, 1,2-dihydroisoquinoline derivatives act as delivery systems that transport drugs through the otherwise highly impermeable blood-brain barrier [4,5]. Isoquinoline derivatives also exhibit sedative [6], antidepressant [7,8], antitumor, and antimicrobial activities [9 -11]. Here we describe an efficient one-pot and method for the synthesis of 1,2-disubstituted 1,2-dihydroisoquinoline derivatives via the reaction of isoquinoline (1), a dialkyl acetylenedicarboxylate 3 and a N-phenylcarbamate 2 under solvent-free conditions at room temperature (Scheme 1).…”