Synthesis and Neurotropic Properties of 1‐Aryl‐4‐(3′,4′,5′‐trimethoxybenzoyl)piperazines

Abstract

Pyrazine derivatives R 0550Synthesis and Neurotropic Properties of 1-Aryl-4-(3',4',5'-trimethoxybenzoyl)piperazines -[synthesis of 7 analogues of (III), remarkable anxiolytic activity only observed for derivative (III)]. -(SOBOLEVA, S. G.; GALATIN, A. F.; KARASEVA, T. L.; GOLTURENKO, A. V.; ANDRONATI, S. A.; Khim.-Farm. Zh. 39 (2005) 5, 12-14; Mechnikov Odessa State Univ., Odessa 65026, Ukraine; Russ., Abstr. Eng.) -Mischke 42-179

Reactions of methoxybenzylidene derivatives of 2,2-dimethyl-1,3-dioxane-4,6-dione and their saturated analogs with certain nucleophilic reagents

“…5a 3.87 (6H, s, 2OCH3); 3.88 (6H, s, 2OCH3); 6.91 (2H, d, J = 9.0, arom); 7.00 (2H, dd, J = 9.0, J = 3.2, arom); 7.68 (2H, d, J = 3.2, arom); 9.10 (2H, s, 2СН=) 5b3.87 (12H, br. s, 4 OCH3); 6.46 (2H, d, J = 2.3, arom); 6.58 (2H, d, J = 8.2, arom); 8.10 (2H, br.…”

“…The methoxyphenyl substituent is a structural fragment of a large number of pharmaceutical preparations, the best known of which are drugs with a stimulating action on the cardiovascular system [1, 2] and neurotropic activity [3].…”

“…The 1,2-bis(methoxybenzylidene)hydrazines, amides, and hydrazides of methoxybenzylidenemalonic acid, suitable for use as structural blocks in the synthesis of various structures based on them, were prepared and characterized.The methoxyphenyl substituent is a structural fragment of a large number of pharmaceutical preparations, the best known of which are drugs with a stimulating action on the cardiovascular system [1, 2] and neurotropic activity [3].As starting materials containing the above-mentioned fragment for the synthesis of new compounds, unknown in the literature, we chose the methoxybenzylidene derivatives of 2,2-dimethyl-1,3-dioxane-4,6-dione 3 and their saturated analogs 4. Compounds 3 are the products from the condensation of methoxy-substituted benzaldehydes 1 with 2,2-dimethyl-1,3-dioxane-4,6-dione (isopropylidenemalonate, Meldrum's acid) (2).…”