Synthesis and odour perception of a series of highly substituted cyclohexane derivatives

Abstract

A series of novel‐substituted cyclohexane derivatives has been prepared and their olfactory evaluation is presented. The different structures are derived from the cyclization of an unsaturated ketal under catalytic conditions. Its further functionalization allowed for the preparation of a series of 22 new compounds. Most of the new cyclic compounds present fruity and/or woody notes.

Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent Progress

“…The addition of unsaturated hydrocarbons is part of a large group of reactions with broad application in the fragrance industry. Many achievements have been made in the synthesis of acyclic and carbocyclic fragrances via addition-type reactions, including recent progress using asymmetric addition and hydrogenation for fragrances [ 119 , 120 , 121 , 122 , 123 , 124 , 125 ]. In this section, we would like to highlight one undervalued direction, using addition-type reactions for heterocyclic fragrances.…”