Synthesis and optimization of 1-pyrrolemethane sulfonate by means of experimental design

Abstract

This paper gives one approach of how to use experimental design in order to increase the yield for an organic synthesis. In this case the synthesis of 1-pyrrolemethane sulfonate was optimised. Two types of designs were used. First a series of screening experiments using fractional factonal design was applied.From these experiments a model was determined and used to locate the next experimental domain. The following experiments were planned as a Doehlert design in order to obtain a response surface model. "he optimum was estimated and confirmed experimentally. O 1996 by John Wiley & Son, Ltd.