Synthesis and Pharmacological Activities of Pyrano[2,3-d]pyrimidine and Pyrano[2,3-d]pyrimidine-5-one Derivatives as New Fused Heterocyclic Systems

Abstract

Various fused oxazine such as 4-(4-methoxyphenyl)-3,7-dimethyl-1,4-dihydro-5H-pyrazolo [4 ,3 :5,6]

3D‐pharmacophore study molecular docking and synthesis of pyrido[2,3‐d]pyrimidine‐4(1H) dione derivatives with in vitro potential anticancer and antioxidant activities

“…In continuation of our program aiming to synthesize polyfunctional substituted heterocyclic compounds of potential biological activity, [ 3,4,8,17,18,23–29 ] the synthesis of poly‐functionalized 7‐amino‐5‐(4‐methoxyphenyl)‐2,4‐dioxo‐1,2,3,4‐tetrahydropyrido[2,3‐ d ]pyrimidine‐6‐carbonitrile ( 1a ) and 2‐amino‐4‐(4‐methoxyphenyl)‐5‐oxo‐5 H ‐dipyrido[1,2‐a:3′,2′‐ e ]pyrimidine‐3‐carbonitrile ( 1b ) was achieved via one‐pot multicomponent reactions of the barbituric acid and/or 3 H ‐pyrido [1,2‐ a ]pyrimidine‐2,4‐dione, [ 26 ] anisaldehyde, ammonium acetate and malononitrile or three‐component reactions of barbituric acid and/or 3 H ‐pyrido[1,2‐ a ]pyrimidine‐2,4‐dione, arylidine of malononitrile and ammonium acetate, under fusion at 150°C (Scheme 1).…”

One‐pot effective synthesis of new heterocyclic system: Pyrano[4′,3′:4,5]pyrido[2,3‐d]pyrimidin‐6‐one

“…The pyridine moiety fused with pyrimidine constitutes important nitrogen-containing heterocyclic class that has been associated with diverse biological properties [4,5].…”

Syringaldehyde as a scaffold for the synthesis of some biologically potent heterocycles

“…Therefore, its synthesis has become an urgent demand. [29,30] For the above mentioned importance of syringaldehyde, and in continuation of our interest in the synthesis of biologically active compounds, [31][32][33][34][35][36] herein, we submitted syringaldehyde as a specific synthon for the synthesis of some heterocyclic derivatives which may have promising biological activity. Some of the synthesized compounds were tested for antioxidant activity where they showed ability to inhibit oxidation in kidney and rat brain homogenates using 2, 2 0azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS).…”