Synthesis and pharmacological activity of 1,4-diazepino[3,2,1-hi]-indoles

Substrate-Controlled Three-Component Synthesis of Diverse Fused Heterocycles

“…1 H NMR (400 MHz, DMSO-d 6 ) δ 7.34−7.26 (m, 1H), 7.26−7.17 (m, 2H), 7.17−7.10 (m, 1H), 6.26 (s, 1H), 4.89 (s, 1H), 4.10−4.00 (m, 2H), 3.95 (q, J = 7.0 Hz, 2H), 3.90−3.82 (m, 2H), 3.14 (s, 6H), 2.32 (s, 3H), 1.10 (t, J = 7.0 Hz, 3H). 13 (16). Synthesized using 2-mesityl-2-oxoacetaldehyde hydrate (8c•H 2 O, 58 mg, 0.3 mmol).…”

“…Rigidin A, the parent compound of the family, exhibited calmodulin antagonistic activity while certain synthetic rigidin analogues showed some promise as anticancer agents presumably targeting the colchicine binding site of tubulin . 4 H -Benzo­[ d ]­pyrrolo­[1,2- a ]­imidazole 14 showed promising in vitro antiarrhythmic and antioxidant activities as well as in vivo hypoglycemic and antihypotensive effects . Taking into account the useful properties of the above molecules, it can be concluded that the research on the new methodologies to access 1,4-dihydropyridine- and pyrrole-based fused polyheterocycles such as those featured in the present study is highly warranted.…”

“…15 4H-Benzo [d]pyrrolo [1,2a]imidazole 14 showed promising in vitro antiarrhythmic and antioxidant activities as well as in vivo hypoglycemic and antihypotensive effects. 16 Taking into account the useful properties of the above molecules, it can be concluded that the research on the new methodologies to access 1,4-dihydropyridine-and pyrrole-based fused polyheterocycles such as those featured in the present study is highly warranted.…”