Synthesis and pharmacological activity of furo-1,4-dihydropyridines

Synthesis and crystal structure of 2,6-bis(N-cytisinomethyl)-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

“…Scientists of the Latvian Institute of Organic Synthesis have carried out an enormous study in executing the systematic synthesis of numerous derivatives of 1,4-dihydropyridines with the aim of searching for new cardiotonic and ionotropic preparations, and clarification of structure-activity relationships [12][13][14].…”

“…Compounds were also discovered among the derivatives of 1,4-dihydropyridines with no less valuable pharmacological properties (antibacterial, antiviral, antidiabetic, hepatoprotecting, antiulcer, etc) [4-6], which make further searches in the 1,4-dihydropyridine series extremely urgent. Up to the present time an enormous number of symmetrical and unsymmetrical derivatives of 1,4-dihydropyridine with various functional substituents has been synthesized, and a great number of methods of obtaining them (including microwave) has been developed by further conversions and aromatization [7][8][9][10][11].Scientists of the Latvian Institute of Organic Synthesis have carried out an enormous study in executing the systematic synthesis of numerous derivatives of 1,4-dihydropyridines with the aim of searching for new cardiotonic and ionotropic preparations, and clarification of structure-activity relationships [12][13][14].However, in spite of the enormous number of synthesized derivatives of 1,4-dihydropyridines, no compounds combining in their structure a 1,4-dihydropyridine ring and certain physiologically active alkaloids have been described in the literature. It therefore seemed of interest to synthesize previously unknown 1,4-dihydropyridine derivatives from certain alkaloids, in particular, cytisine.…”