Synthesis and Pharmacological Activity of Urea and Thiourea Derivatives of 4‐Azatricyclo[5.2.2.0^2,6]undec‐8‐ene‐3,5‐dione.

Abstract

2,6 ]undec-8-ene-3,5-dione. -The compounds (I) and (II) are completely inactive towards bacteria and fungi and do not show any activity against HIV-1. (IIa) does not protect from clonic seizures and tonic convulsions evoked by pentetrazole. -(STRUGA*, M.; KOSSAKOWSKI, J.; KEDZIERSKA, E.; FIDECKA, S.; STEFANSKA, J.; Chem. Pharm. Bull. 55 (2007) 5, 796-799; Dep. Med. Chem., Med. Univ., PL-02-007 Warsaw, Pol.; Eng.) -K. Woydowski 45-198

Synthesis of new 1,3‐thiazepine derivatives

“…In order to obtain the corresponding thiourea derivatives of above compounds they were subjected to the reaction with phenyl-, 4-methoxyphenyl-, cyclohexylisothiocyanate [27].…”

“…Obtained tricyclic anhydrides or imides were subjected to the reaction of hydrazine (80 % aqueous solution) as described previously [26,27].…”

Synthesis of new derivatives of 2,2-dimethyl-2,3-dihydro-7-benzo[b]furanol with potential antimicrobial activity

“…Gram-negative and Gram-positive bacterial strains and fungi used in this study have common application in the antimicrobial activity tests for many substances such as antibiotics, disinfections, and antiseptic drugs and in research of new antimicrobial agents (Orzeszko et al, 2004;Struga et al, 2007Struga et al, , 2008.…”

A Molecular Docking Study of N-Ferrocenylmethylnitroanilines as Potential Anticancer Drugs

“…It catalyses the breakage of a DNA duplex (the G segment), the passage of another segment (the T segment) through the break, and then the reunification of the break, this activity involves the opening and dosing of a series of molecular 'gates' which is coupled to ATP hydrolysis [2]. Ferrocene derivatives has drawn interest due to their stable chemical structure and large variety of biological properties [3][4][5][6][7][8][9][10][11][12][13][14], ferrocenes incorporated heterocyclic ring systems have a huge potential to become successful drug candidates which was proven in the recent past few years [15][16]. Ferrocenylmethylnitroanilines exhibit diverse biological activities such as antioxidant activities [17].…”