2024
DOI: 10.1101/2024.06.14.598980
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Synthesis and pharmacological characterization of UVI3502, a novel cannabinoid receptor 1 (CB1) antagonist/inverse agonist

Iker Bengoetxea de Tena,
Gorka Pereira-Castelo,
Jonatan Martínez-Gardeazabal
et al.

Abstract: The endocannabinoid (eCB) system regulates several brain functions and is implicated in neurological disorders. The pharmacological blockade of cannabinoid receptors has a therapeutic potential for various cognitive deficits, but also produces severe psychiatric side effects. Hence, new cannabinoid compounds that potentiate therapeutic effects, while minimizing toxicity, are required. In this study, we synthesized and characterized a novel antagonist/inverse agonist of CB1receptors. UVI3502 showed affinity for… Show more

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