Synthesis and pharmacological evaluation of some novel 2-(5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(coumarin-3-yl)thiazoles

One-pot multicomponent synthesis of novel 1-thiazolyl-5-coumarin-3-yl-pyrazole derivatives and evaluation of their cytotoxic activity

“…Several pyrazole derivatives possess a wide range of biological activities such as anticancer [6], antimicrobial [7], antiviral [8], antitubercular [9], antioxidant [10], anti-inflammatory [11], antidepressant and anticonvulsant [12] activities. Pyrazole scaffolds are not only independent, along with other heterocycles like thiazole and coumarins, but also possess marked biological activities [13][14][15][16][17][18]. Thiazoles and coumarins also portray an important role in medicinal and pharmaceutical chemistry due to their versatile biological applications, such as antimicrobial [19,20], anticancer [21,22], antitumor [23,24], antiulcer [25,26], antiviral [27,28], antioxidant [29,30], anticonvulsant [31,32] and antihypertensive [33,34] activities.…”

Diastereoselective One‐Pot Synthesis of Coumarin‐4‐carboxamido‐3‐esters via a Four‐Component Isocyanide‐Based Reaction and Molecular Docking Study

“…In many studies, the substitutions at C‐3 and C‐4 of the coumarin nucleus resulted in improved biological activity, such as the cytotoxic and anti‐inflammatory potency,,, compared to the simple coumarin molecule. For example, in recent works, synthesis of some substituted coumarin derivatives bearing a thiazole or pyrazole unit have been reported to possess antimicrobial, analgesic and anti‐inflammatory activities (Scheme ).…”

“… Some coumarin containing biological active heterocycles including thiazole, pyrazole moieties, i ii‐v …”

Antidiabetic effect, antioxidant activity, and toxicity of 3′,4′-Di-O-acetyl-cis-khellactone in Streptozotocin-induced diabetic rats

“…9,15,16 The increase in ROS can lead to death of Beta cells; therefore, an improvement in BW may be due to that DOAcK carries out better control of hyperglycemia by decreasing ROS. 17 Coumarins and their derivatives have attracted attention due to their antiinflammatory, antibacterial and antiarthritic activities, 18,19 as well as antidiabetic agents. In some studies it has been reported that different coumarins and pyranocoumarins decreasing blood glucose by up to 42%, 9 and in some cases it has been demonstrated that this improvement is due to changes in the activity of Glucose-6-phosphatase and Fructose-1,6-bisphosphatase.…”