Synthesis and pharmacological evaluation of some benzylidene-4-nitroanilines

Abstract

A number of nine benzylidene-4-nitroanilines were synthesized by condensation method. The formation of the substituted (E)-N-benzylidene-4-nitrobenzenamines has been confirmed from their physical and Ultra-Violet, Infra-Red, NMR spectral data. The evaluation of antimicrobial screening of substituted (E)-N-benzylidene-4-nitrobenzenamines was conducted by using standard Bauer-Kirby method. Three gram-positive microbes namely Bacillus subtilis, Micrococcus luteus and Staphylococcus aureus, and two gram-negative microbes, Escherichia coli and Pseudomonas aeruginosa, were used for the antibacterial evaluation. The antifungal activities against Aspergillus niger and Penicilium scup fungal species were also performed. A good antibacterial effect has been possessed by some of the substituted (E)-N-benzylidene-4-nitrobenzenamines on the microorganisms utilized in the present study

Ultrasound assisted synthesis and spectral correlations of some bio-active E-imines

“…The antibacterial effect of the substituted (E)-N-benzylidene-4-morpholinoanilines is shown in Fig. 4 and the zone of inhibition values [18, 23,24,25,27,[50][51][52][53][54][55][56][57][58][59][60][61] are given Table 9. The corresponding clustered column chart is given in Fig.…”