Synthesis and Pharmacological Evaluation of Some Novel Imidazo[2,1‐b][1,3,4]thiadiazole Derivatives

Synthesis, characterization and antimicrobial activity evaluation of new imidazo [2,1-b][1,3,4]thiadiazole derivatives

“…During recent years, there have been intense investigations on thiadiazole and imidazo [2,1-b] [1,3,4]thiadiazole compounds, many of which are known to possess interesting pharmacological properties such as anticancer [7], antitubercular [8], antibacterial [9], antifungal [10], antimicrobial and anti-inflammatory [11,12], analgesic and antimicrobial [13], anticonvulsant, analgesic [14], and antisecretory [15] activities. Moreover, much interest has also been focused on the cardiotonic [16], diuretic [17] and herbicidal [18] activities displayed by compounds incorporating this heterocyclic system.…”

Heterocyclic Systems Containing Bridgehead Nitrogen Atom:Synthesis and Evaluation of Biological Activity of Imidazo[2,1-b]-1,3,4-thiadiazolo [2,3-c]-s-triazoles, s-Triazolo[3,4-b]-1,3,4-thiadiazolo[3,2-b]imidazo[4,5-b]quinoxaline and bis-(s-Triazolo[3,4-b]-1,3,4-thiadiazolo[3,2-b][imidazo[4,5-b]-cyclohexane]-5a,6a-diene)

“…Encouraged by these observation and in continuation of our earlier studies on the synthesis of biological active heterocyclic compounds, 14,16,17 we report herein, the synthesis of 3,9-di-(α-naphthyl)-6,14-dioxo-bis- …”

“…2). Imidazole is one of the most fascinating classes of compounds possessing variety of biological activities 13,14 such as anti-HIV, anti-histamine, antibacterial, tranquillizer etc. Quinoxaline systems are also important class of compounds that present in certain important biological compounds 15 such as folic acid, riboflavin and pyocyanine.…”

An environmentally benign and solvent-free synthesis of 3-aryl[1,2,4]triazolo[4,3-a]pyridines and 1-aryl-5-methyl[1,2,4]triazolo[4,3-a]quinolines using phenyliodine bis(trifluoroacetate) or iodobenzene diacetate

“…It brings advantages from the environmental point of view, as well as rate enhancement, less waste products, and higher yields [32]. In continuation of our previous work [16,[33][34][35][36][37] on biologically active heterocyclic compounds and development of novel synthetic methodologies and because of the biological significance of 1,2,4-triazole, a solvent-free oxidative cyclization of 2-pyridyl-and 2-quinolylhydrazones with phenyliodine bis(trifluoroacetate) (PIFA) or iodobenzene diacetate (IBD) to the corresponding 3-aryl-[1,2,4]triazolo[4,3-a]pyridines and 1-aryl-5-methyl-[1,2,4]triazolo[4,3-a]quinolines is reported here.…”