Synthesis and pharmacological evaluation of some tetrahydrooxadiazinones and some dihydroaminooxadiazines

(5S)-4-(2,2-Dimethylpropyl)-5-isopropyl-1,3,4-oxadiazinan-2-one

“…For related structures and background, see: Addison et al (2008); Anderson et al (2006); Burgeson et al (2004); Casper et al (2002); Rodrigues et al (2006); Szczepura et al (2004); Trepanier et al (1968). The synthesis of the title compound is described by Casper et al (2004).…”

(5S,6R)-5-Methyl-6-phenyl-4-propyl-1,3,4-oxadiazinane-2-thione

“…For background, see: Hitchcock et al (2002Hitchcock et al ( , 2008; Trepanier et al (1968). For related compounds, see: Burgeson et al (2004) ;Casper, Blackburn et al (2002) ;Casper, Burgeson et al (2002); Cremer & Pople (1975); Ferrence et al (2003); Hitchcock et al (2001Hitchcock et al ( , 2004; Rodrigues et al (2005Rodrigues et al ( , 2006; Squire et al (2005); Szczepura et al (2004).…”

“…The heterocyclic structure of 1,3,4-oxadiazinan-2-one compounds have been known for nearly forty years, however the related compound 3,4,5,6-tetrahydro-2H-1,3,4-oxadiazinan-2-thione has just within the last 10 years been synthesized and studied (Trepanier et al, 1968;Hitchcock et al, 2002). Other oxadiazinanones, but no oxadiazinanthiones, have been reported and studied.…”

(5R,6S)-4-Isopropyl-5-methyl-6-phenyl-3-propanoyl-2H-1,3,4-oxadiazinan-2-one

“…Oxazolidin-2-ones, chiral auxiliaries first introduced by Evans et al (Evans et al, 1981), have been of substance in areas of alkylation reactions, pericyclic reactions, and asymmetric aldol condensation reactions. Related, 1,3,4-oxadiazinan-2-one heterocycles have received little interest since their disclosure (Trepanier et al, 1968). It was not until recently that synthetic (Hitchcock et al, 2001) and conformational studies (Casper, Burgeson et al, 2002) of 1,3,4-oxadiazinan-2-one have been thoroughly performed.…”