Synthesis and Pharmacological Screening of Difluorophenyl Pyrazole Chalcone Conjugates as Antifungal, Anti-Inflammatory, and Antioxidant Agents

Synthesis and Characterization of Novel Heterocyclic Chalcones from 1-Phenyl-1H-pyrazol-3-ol

“…An in-depth analysis of NMR spectral data, which were obtained through a combination of standard and advanced NMR spectroscopy techniques, such as 1 H- 13 C HMBC, 1 H- 13 C HSQC, 1 H- 13 C H2BC, 1 H- 15 N HMBC, 1 H- 15 N LR-HSQMBC, 1 H-1 H TOCSY, 1 H-1 H COSY, 1 H-1 H NOESY and 1,1-ADEQUATE experiments, provided the key information in the establishment of structural assignments and predominant configuration, due to conformations in a solvent of novel pyrazole-chalcones. The synthesis and biological activity of the related compounds has been reported in previous works, but no data on conformational analysis supported by NMR experiments were given [58][59][60][61].…”

Chalcone Scaffold: A masterpiece for medicinal chemistry recent biological insights

“…A series of difluoro phenyl pyrazole chalcone derivatives (8, Fig. 6) were reported by S. Y. Jadhavn et al against several human pathogenic fungi, showing promising antifungal activity at MIC of 25 g/mL against T. harzianum [38].…”

Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis

“…In another study, several difluoro phenyl pyrazole chalcone-based compounds were prepared and their activities against human pathogenic fungi were evaluated in vitro. It was indicated that a number of these compounds displayed promising inhibitory effects (MICs of 25 and 50 μg/mL) [ 151 ]. In a different study, ferrocenyl chalcone and organic chalcone were used as intermediates to synthesize sulfones and bis-sulfones and their fungicidal activities were investigated.…”