Synthesis and Photophysical Characterization of a Photoaffinity Molecular Switch

Abstract

In recent years, the development of some photoswitches based on azobenzene group provides a good tool for high spatio-temporal and precise regulation of ion channels and protein receports, but these small molecular photoswitches are very easily diffused in organisms. To overcome this limit, we have designed a photoswitches SY1 containing photocrosslinked group diazirine. The photoswitch was synthesized by the condensation reaction between azobenzene derivative and diazirine. The structure of the compound was characterized by 1 H NMR and HR-MS, and the photophysical properties of the photoswtich SY1 were studied by UV-vis spectroscopy in different solvent systems. The results show that SY1 has excellent photodependent isomerization.